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Childhood Antecedents of Adult Cardiometabolic health: A Prospective Study of Low-Income Men

Award Number: R01HL152444
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Childhood Antecedents of Adult Cardiometabolic health: A Prospective Study of Low-Income Men - Project Summary/Abstract Cardiovascular disease (CVD) and diabetes are leading causes of death among adults in the US, with incident disease following years of accumulating risk conferred through various metabolic pathways (obesity, dyslipidemia, insulin resistance), immune factors (e.g., systemic inflammation), and rising blood pressure. The pathogenesis of CVD and cardiometabolic health begins in childhood, thus it is imperative to identify factors that contribute to emerging cardiometabolic health disparities. Like other chronic diseases, CVD and diabetes track a socioeconomic gradient, with greater lifelong health risk among individuals born into disadvantaged circumstances. However, no prospective studies have carefully characterized links between early socioeconomic disadvantage and adult health, addressing whether poverty during particular developmental stages is especially harmful and delineating developmentally salient risk factors that may link economic disadvantage to cardiometabolic disease (CMD) risk. Guided by the family stress framework, we propose that family-, school- and community-level factors during critical phases of development are pathways through which socioeconomic disadvantage in childhood shapes cardiometabolic health. We also consider the role of child- based protective factors that might buffer the effects of poverty on adult health outcomes. Finally, we explore how race and SES intersect to shape risk for CMD in adulthood and whether adult health behaviors are pathways through which economic disadvantage gives rise to greater propensity for CMD. The project will assess the cardiovascular health of a diverse sample of 248 adult men (aged 31-33 years) who participated in the Pittsburgh Mother & Child Project (PMCP). The parent project recruited a sample of 310 toddlers from low income families and has followed them closely to early adulthood, permitting a comprehensive assessment of risk and protective factors. We will consider whether these factors relate to biomarkers of cardiometabolic health risk and preclinical markers of CVD – carotid intima media thickness and pulse wave velocity. By testing novel contextual pathways at the family, school, and neighborhood levels this investigation will help to identify contexts that can be targeted by programs and policies aimed at reducing socioeconomic disparities in adult health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $715,152 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	4	8/16/2024	NON-COMPETING CONTINUATION	$715,152
														Subtotal = $715,152

Issue Date FY: 2023 ( Subtotal = $774,672 )
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	001	3	7/27/2023	SUPPLEMENT FOR EXPANSION	$31,918
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	3	7/24/2023	NON-COMPETING CONTINUATION	$742,754
														Subtotal = $774,672

Issue Date FY: 2022 ( Subtotal = $836,918 )
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	001	2	8/6/2022	NON-COMPETING CONTINUATION	$718,631
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	002	2	8/9/2022	SUPPLEMENT FOR EXPANSION	$75,330
2022	2022	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	1	1/15/2022	SUPPLEMENT FOR EXPANSION	$42,957
														Subtotal = $836,918

Issue Date FY: 2021 ( Subtotal = $763,948 )
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	1	7/17/2021	NEW	$763,948
														Subtotal = $763,948

Grand Total All Awards = $3,090,690

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Childhood Antecedents of Adult Cardiometabolic health: A Prospective Study of Low-Income Men

Award Number: R01HL152444

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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