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Cardiac MRI increases accuracy and decreases risk of evaluation of children with cardiomyopathy and cardiac transplantation

Award Number: R01HL144494
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Cardiac MRI increases accuracy and decreases risk of evaluation of children with cardiomyopathy and cardiac transplantation - Project Summary: Children with cardiomyopathy from any cause (genetic, congenital heart disease or myocarditis) require extensive evaluation, including endomyocardial biopsy (EMB), hemodynamic cardiac catheterization, and angiography guided by x-ray, in preparation for, and as routine surveillance following, cardiac transplantation. These invasive tests are the gold standard for determining suitability for transplant and for detection of complications of heart transplant, but also carry risks of invasive procedures and radiation exposure. New cardiac magnetic resonance (CMR) imaging methods called parametric mapping images have emerged to both detect and quantify fibrosis (T1 mapping) and edema (T2 mapping) within cardiac muscle. Preliminary data shows promise in detection transplant rejection and extent of preclinical transplant failure noninvasively in adult pre/post transplant patients. In addition, we have published our experience in using CMR to guide radiation-free hemodynamic catheterization in children and guide radiation- reduced cardiac interventions in the x-ray suite in children. We are well-positioned to accomplish our overarching goal, which is to create a lower risk, radiation- reduced regimen for cardiac assessment in pediatric pre/post transplant patients using CMR imaging that correlates with and predicts invasive testing results (Aim #1), guides invasive EMB with better soft-tissue visualization (Aim #2) and reduces radiation exposure by guiding hemodynamic catheterization assessment (Aim #3). We believe that all patients with cardiomyopathy and heart failure may benefit from completion of this project.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	5	11/5/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $486,915 )
2023	2023	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	001	5	11/17/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$439,695
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	003	5	3/11/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$47,220
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	006	5	6/26/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$943,162
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	002	5	12/9/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2023	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	005	4	6/26/2023	NON-COMPETING CONTINUATION	-$761,184
2023	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	000	4	11/16/2022	NON-COMPETING CONTINUATION	$0
2023	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	004	3	6/26/2023	NON-COMPETING CONTINUATION	-$181,978
														Subtotal = $486,915

Issue Date FY: 2022 ( Subtotal = $761,184 )
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	001	4	6/29/2022	NON-COMPETING CONTINUATION	$76,120
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	000	4	1/20/2022	NON-COMPETING CONTINUATION	$685,064
														Subtotal = $761,184

Issue Date FY: 2021 ( Subtotal = $772,393 )
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	001	3	5/19/2021	NON-COMPETING CONTINUATION	$77,241
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	000	3	12/30/2020	NON-COMPETING CONTINUATION	$695,152
														Subtotal = $772,393

Issue Date FY: 2020 ( Subtotal = $786,759 )
2020	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	002	2	3/7/2020	NON-COMPETING CONTINUATION	$39,339
2020	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	001	2	1/10/2020	NON-COMPETING CONTINUATION	$747,420
2020	2019	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	000	1	12/3/2019	NEW	$0
														Subtotal = $786,759

Issue Date FY: 2019 ( Subtotal = $773,729 )
2019	2019	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Cardiovascular Diseases Research	000	1	2/14/2019	NEW	$773,729
														Subtotal = $773,729

Grand Total All Awards = $3,580,980

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Cardiac MRI increases accuracy and decreases risk of evaluation of children with cardiomyopathy and cardiac transplantation

Award Number: R01HL144494

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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