Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Longitudinal Mechanisms of Food and Nutrition Security and Cardiometabolic Health in PROSPECT

Award Number: R01HL143792
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2029

Group Awards By:

View Award Description

Longitudinal Mechanisms of Food and Nutrition Security and Cardiometabolic Health in PROSPECT - PROJECT SUMMARY Access to sufficient, high-quality, and safe food and nutrition is a fundamental human right. Lacking this denotes food insecurity (FI), becoming a significant societal and public health crisis. FI increases the risk of type 2 diabetes and cardiovascular disease. Yet, there is insufficient evidence on the causal link and potential mediating mechanisms between FI and cardiometabolic disease (CMD). Posited pathways are neuroendocrine factors, dietary factors, such as dysfunctional eating or specific fats like trans fats or ceramides, and positive or negative psychological factors. But few studies have investigated these pathways. It is also unclear how persistent vs. transient FI influences CMD. Moreover, the impact of food procurement decisions on FI and diet quality has been barely studied. These gaps are largely due to scant comprehensive longitudinal studies, leading key agencies to call for rigorous research on the mechanisms linking FI and CMD in vulnerable groups. Due to social and cardiovascular-related inequities, compounded by vulnerability to climate-change events, FI prevalence in the US territory of Puerto Rico (PR) is 33.2%, three times the US prevalence. This makes PR a pressing case and an ideal setting to study contributors to - and health consequences of - FI. With the goal of elucidating the complex pathways connecting FI and CMD, in 2018 we established PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic disease Trends (R01-HL143792), a longitudinal cohort of adults aged 30-75 y. PROSPECT includes a thorough clinical examination and collects blood, urine, saliva, and hair samples to assess CMD, and validated psychosocial measures, a food frequency questionnaire, geocoded food access metrics, and the USDA Food Security Survey Module. Our reports show that 73% of participants have abdominal obesity, 61% have high blood pressure, 33% have FI, and 53% receive the Nutrition Assistance Program. We propose to renew PROSPECT to assess CMD at 4y and 6y post-baseline, screen for transient FI between visits, and analyze circulating fatty acids and novel biomarkers. We will enrich representation from rural areas and men, key CVD factors, with 500 new participants. Over 6y, we aim to determine associations between persistent and transient FI and CMD, directly or via neuroendocrine markers; identify dietary and psychosocial mechanisms linking FI and CMD; and identify food procurement factors associated with FI and diet. Exploratory analysis will georeference climate change indicators with FI. PROSPECT leverages an established interdisciplinary team, a thorough dataset, multiple timepoints to examine complex pathways, novel biomarkers, and original analysis of FI and climate-change events. We have already produced pivotal publications, action-oriented initiatives, ancillary studies, and a biorepository and research infrastructure in PR. This renewal will enhance our unique cohort and generate compelling results that will advance science by elucidating mechanisms between FI and CMD, serving as model for other groups, and will inform food-related and psychosocial programs to alleviate FI and CMD inequities in PR and beyond.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,732,961 )
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Cardiovascular Diseases Research	002	8	5/6/2026	NON-COMPETING CONTINUATION	$1,732,961
2026	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Cardiovascular Diseases Research	000	7	1/30/2026	NON-COMPETING CONTINUATION	$0
2026	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Cardiovascular Diseases Research	001	6	4/23/2026	COMPETING CONTINUATION	$0
														Subtotal = $1,732,961

Issue Date FY: 2025 ( Subtotal = $1,802,030 )
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Cardiovascular Diseases Research	001	7	7/31/2025	NON-COMPETING CONTINUATION	$1,802,030
2025	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	3/27/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,802,030

Issue Date FY: 2024 ( Subtotal = $1,884,576 )
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Cardiovascular Diseases Research	001	6	4/30/2024	COMPETING CONTINUATION	$1,884,576
2024	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	4/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,884,576

Issue Date FY: 2022 ( Subtotal = $617,462 )
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	5	5/25/2022	NON-COMPETING CONTINUATION	$617,462
														Subtotal = $617,462

Issue Date FY: 2021 ( Subtotal = $762,215 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	4	7/28/2021	SUPPLEMENT FOR EXPANSION	$138,490
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	4	8/17/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	4	5/20/2021	NON-COMPETING CONTINUATION	$623,725
														Subtotal = $762,215

Issue Date FY: 2020 ( Subtotal = $627,985 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	7/16/2020	NON-COMPETING CONTINUATION	$627,985
														Subtotal = $627,985

Issue Date FY: 2019 ( Subtotal = $633,120 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	6/29/2019	NON-COMPETING CONTINUATION	$633,120
														Subtotal = $633,120

Issue Date FY: 2018 ( Subtotal = $667,658 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	6/25/2018	NEW	$667,658
														Subtotal = $667,658

Grand Total All Awards = $8,728,007

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Longitudinal Mechanisms of Food and Nutrition Security and Cardiometabolic Health in PROSPECT

Award Number: R01HL143792

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer