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Assessment of Policies through Prediction of Long-term Effects on Cardiovascular Disease Using Simulation (APPLE CDS)

Award Number: R01HL141427
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Assessment of Policies through Prediction of Long-term Effects on Cardiovascular Disease Using Simulation (APPLE CDS) - Project Summary/Abstract Dietary behaviors are key modifiable risk factors in averting cardiovascular disease (CVD), the leading cause of morbidity, mortality, and disability in the United States (US). Despite national and local initiatives to promote healthy dietary behaviors, unhealthy diets remain a difficult, perplexing population health problem requiring initiatives and solutions at the community and population levels. Prior to investing in implementation, health practitioners and policymakers—often working with limited resources—need to compare the population health impact of different food policies and programs to then determine priorities. The goal of this project, Assessment of Policies through Prediction of Long-term Effects on Cardiovascular Disease Using Simulation (APPLE CDS), is to compare the effects of food policies and programs on CVD-related outcomes and health care costs for adults. This will be useful to aid local government and community organizations in priority setting and decision-making. Policy and program assessment will be conducted using agent-based modeling, an efficient, novel technique that has been underutilized in public health research. We assembled a team of experts in CVD, nutrition, public health, health economics, and computer simulation modeling who are committed to working together to identify realistic pathways that can be used to improve dietary behaviors. The Specific Aims are to: (1) develop an agent-based model to assess and compare the impact of alternative food policies and programs on dietary behaviors, blood pressure, body mass index (BMI), and diabetes across different neighborhoods in NYC and (2) link the agent-based model with the well-established, validated NYC CVD Policy Model to project the long-term impact of different food policies and programs on cardiovascular disease outcomes (e.g., hypertension, coronary heart disease, stroke), quality-adjusted life years (QALYs), and health care costs. We will leverage the rich community-level health data on dietary behaviors collected by the NYC Department of Health and Mental Hygiene (DOHMH) to parameterize and validate the model. In addition, our close partnerships with the NYC DOHMH and a broad range of community-based organizations across the city will ensure that simulation results will be used to select and optimize implementation of the most cost-effective, neighborhood-specific food policies and programs to improve population health. Finally, the NYC experience can serve as an example by which other local health departments and community-based organizations may make more informed decisions for their own priority setting and program implementation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1,809 )
2024	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	000	4	1/18/2024	SUPPLEMENT FOR EXPANSION	-$1,809
														Subtotal = -$1,809

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	001	4	8/19/2022	NON-COMPETING CONTINUATION	$0
2022	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	000	4	8/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $869,820 )
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	004	4	6/24/2021	NON-COMPETING CONTINUATION	$701,082
2021	2021	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	005	4	6/25/2021	SUPPLEMENT FOR EXPANSION	$168,738
2021	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	003	3	3/15/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$921,669
2021	2019	NEW YORK ACADEMY OF MEDICINE	1216 5TH AVE	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	002	2	3/15/2021	SUPPLEMENT FOR EXPANSION	-$126,447
2021	2019	NEW YORK ACADEMY OF MEDICINE	1216 5TH AVE	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	001	2	3/15/2021	NON-COMPETING CONTINUATION	-$773,785
2021	2018	NEW YORK ACADEMY OF MEDICINE	1216 5TH AVE	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	000	1	3/15/2021	NEW	-$21,437
														Subtotal = $869,820

Issue Date FY: 2020 ( Subtotal = $897,090 )
2020	2020	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	ONE GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	002	3	9/8/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$897,090
2020	2019	NEW YORK ACADEMY OF MEDICINE	1216 5TH AVE	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	000	2	9/1/2020	NON-COMPETING CONTINUATION	$0
2020	2019	NEW YORK ACADEMY OF MEDICINE	1216 5TH AVE	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	001	2	9/1/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $897,090

Issue Date FY: 2019 ( Subtotal = $900,232 )
2019	2019	NEW YORK ACADEMY OF MEDICINE	1216 5TH AVE	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	001	2	8/30/2019	SUPPLEMENT FOR EXPANSION	$126,447
2019	2019	NEW YORK ACADEMY OF MEDICINE	1216 5TH AVE	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	000	2	5/13/2019	NON-COMPETING CONTINUATION	$773,785
														Subtotal = $900,232

Issue Date FY: 2018 ( Subtotal = $843,937 )
2018	2018	NEW YORK ACADEMY OF MEDICINE	1216 5TH AVE	NEW YORK	NY	10029	NEW YORK	USA	Cardiovascular Diseases Research	000	1	8/11/2018	NEW	$843,937
														Subtotal = $843,937

Grand Total All Awards = $3,509,270

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Assessment of Policies through Prediction of Long-term Effects on Cardiovascular Disease Using Simulation (APPLE CDS)

Award Number: R01HL141427

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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