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A novel data science and network analysis approach to quantifying facilitators and barriers of low tidal volume ventilation in an international consortium of medical centers

Award Number: R01HL140362
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/09/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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A novel data science and network analysis approach to quantifying facilitators and barriers of low tidal volume ventilation in an international consortium of medical centers - PROJECT SUMMARY/ABSTRACT This application, “A novel data science and network analysis approach to quantifying facilitators and barriers of low tidal volume ventilation in an international consortium of medical centers,” is in response to PAR-16-238, Dissemination and Implementation Research in Health (R01). Acute respiratory distress syndrome (ARDS) has high prevalence (10% of intensive care unit admissions) and mortality up to 46%. Low tidal volume ventilation (LTVV) is the most effective therapy for ARDS, lowering mortality by 20-25%, and is part of standard practice. However, use of LTVV is as low as 19% of ARDS patients. There is a poor understanding of the barriers to LTVV adoption: current approaches are deficient because they incorporate biases, lack consistency and comprehensiveness, ignore the influence of interpersonal network- or team- based factors, and do not address setting-specific variation. Our research team has previously identified some patient- and clinician-specific facilitators of and barriers to LTVV adoption. We have used two state-of-the-art data driven methods—data science and network analysis—to preliminarily quantify the impact of a diverse array of potential factors affecting LTVV adoption, including network- and team-based factors. The proposed research is guided by the Consolidated Framework for Implementation Research (CFIR) and Rogers' Diffusion of Innovations theory. The overall goals of the proposed research are to understand the differences in facilitators and barriers to LTVV adoption between academic and community settings through a definitive, systematic study in a large, diverse consortium of medical centers, and to advance implementation science by providing a model for how data science and network analysis can be applied to understand the adoption of a complex intervention. The overarching hypothesis is that there are different patient-, clinician-, network-, and team-based facilitators and barriers to LTVV adoption in academic and community settings. We will determine whether different patient- and clinician- (Aim 1 cohort study, clinician survey, and data science analysis), clinician interpersonal network- (Aim 2 network analysis), and team structure and dynamics-based (Aim 3 team construction and modeling) facilitators of and barriers to LTVV adoption exist between academic and community hospital settings. Successful completion of the proposed research will provide a comprehensive understanding of the differences in the facilitators of and barriers to LTVV adoption between academic and community settings, and will advance implementation science by serving as a model of how data science and network analysis can be applied to complex implementation problems. Implementation strategies that account for all these factors may be more likely to lead to significant practice change.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$105,213 )
2025	2022	ENDEAVOR HEALTH CLINICAL OPERATIONS	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Lung Diseases Research	000	5	9/29/2025	NON-COMPETING CONTINUATION	-$105,213
														Subtotal = -$105,213

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	NORTHSHORE UNIVERSITY HEALTHSYSTEM	SUITE 301	EVANSTON	IL	60201	COOK	USA	Lung Diseases Research	000	5	6/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $680,900 )
2022	2022	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Lung Diseases Research	000	5	7/15/2022	NON-COMPETING CONTINUATION	$680,900
														Subtotal = $680,900

Issue Date FY: 2021 ( Subtotal = $680,901 )
2021	2021	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Lung Diseases Research	000	4	6/15/2021	NON-COMPETING CONTINUATION	$680,901
														Subtotal = $680,901

Issue Date FY: 2020 ( Subtotal = $745,390 )
2020	2020	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Lung Diseases Research	000	3	6/2/2020	NON-COMPETING CONTINUATION	$745,390
														Subtotal = $745,390

Issue Date FY: 2019 ( Subtotal = $747,700 )
2019	2019	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Lung Diseases Research	000	2	6/24/2019	NON-COMPETING CONTINUATION	$747,700
														Subtotal = $747,700

Issue Date FY: 2018 ( Subtotal = $793,267 )
2018	2018	NORTHSHORE UNIVERSITY HEALTHSYSTEM	1301 CENTRAL ST	EVANSTON	IL	60201	COOK	USA	Lung Diseases Research	000	1	9/8/2018	NEW	$793,267
														Subtotal = $793,267

Grand Total All Awards = $3,542,945

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A novel data science and network analysis approach to quantifying facilitators and barriers of low tidal volume ventilation in an international consortium of medical centers

Award Number: R01HL140362

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/09/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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