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Lipidomics and structural genomics of cardiometabolic health in Samoan adults

Award Number: R01HL133040
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2017
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Lipidomics and structural genomics of cardiometabolic health in Samoan adults - SUMMARY/ABSTRACT Title: Lipidomics and structural genomics of cardiometabolic health in Samoan adults Project Period: 09/01/2023–08/31/2027 Pacific Islanders, such as Samoans, are disproportionally burdened by cardiometabolic disease yet are un- derrepresented as participants in health research generally, and in genomics research specifically. In this project we will expand the knowledge of lipidomic and genetic structural variation present in Samoans to understand the relationships between the lipidome, simple nucleotide variation, structural genetic, modifiable risk factors, and cardiometabolic health. In our first aim, we will determine associations between comprehensive serum lipid pro- files and both simple nucleotide variation and cardiometabolic traits in 4,300 Samoan adults from Samoa and American Samoa. To achieve this, we will first generate comprehensive lipidomic data, then characterize asso- ciations between the lipidome, modifiable risk factors, and cardiometabolic phenotypes, conduct lipidome-wide association studies of known genetic determinants of lipid variation, and perform genome-wide association stud- ies of the lipidome. In our second aim, we will evaluate associations between structural genetic variation and both comprehensive lipid profiles and cardiometabolic phenotypes by calling structural variation in 1,285 se- quenced Samoan adults, imputing that variation into the larger set of the aforementioned 4,300 Samoan adults, examining associations between structural variation near known genetic determinants of lipidome and cardi- ometabolic variation, and examining associations between genome-wide structural variation and the lipidome and cardiometabolic phenotypes. In our third aim, we will conduct exploratory integrative analyses to identify systems-level patterns among the layers of information available and gathered in the first two aims. Finally, in our fourth aim, we will propose and lead collaborative investigations of our findings with collaborators among the TOPMed Program. our active participation with the Program will enlarge the range of multi-ancestry analyses possible among the participating studies and broaden the impact of this work beyond Samoa. Our discoveries will improve our understanding of the basic biology of lipids and downstream cardiometabolic health outcomes, as well as identify potential targets for interventions to improve cardiometabolic health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,383,053 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	003	7	8/7/2025	NON-COMPETING CONTINUATION	$1,383,053
2025	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	001	6	3/18/2025	COMPETING CONTINUATION	$14,822
2025	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	002	6	6/4/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2021	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	5	3/18/2025	NON-COMPETING CONTINUATION	-$14,822
														Subtotal = $1,383,053

Issue Date FY: 2024 ( Subtotal = $1,516,686 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	6	2/21/2024	COMPETING CONTINUATION	$1,466,436
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	001	6	8/29/2024	SUPPLEMENT FOR EXPANSION	$50,250
														Subtotal = $1,516,686

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	5	7/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $616,083 )
2021	2021	UNIVERSITY OF PITTSBURGH, THE	4200 5TH AVE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	5	3/26/2021	NON-COMPETING CONTINUATION	$616,083
														Subtotal = $616,083

Issue Date FY: 2020 ( Subtotal = $859,208 )
2020	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	002	4	9/23/2020	SUPPLEMENT FOR EXPANSION	$174,072
2020	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	001	4	5/18/2020	NON-COMPETING CONTINUATION	$0
2020	2020	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	000	4	3/25/2020	NON-COMPETING CONTINUATION	$685,136
														Subtotal = $859,208

Issue Date FY: 2019 ( Subtotal = $704,794 )
2019	2019	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	000	3	3/29/2019	NON-COMPETING CONTINUATION	$704,794
														Subtotal = $704,794

Issue Date FY: 2018 ( Subtotal = $690,905 )
2018	2018	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	000	2	5/2/2018	NON-COMPETING CONTINUATION	$690,905
														Subtotal = $690,905

Issue Date FY: 2017 ( Subtotal = $758,337 )
2017	2017	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Cardiovascular Diseases Research	000	1	2/7/2017	NEW	$758,337
														Subtotal = $758,337

Grand Total All Awards = $6,529,066

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Lipidomics and structural genomics of cardiometabolic health in Samoan adults

Award Number: R01HL133040

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2017

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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