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Hippo and Wnt Signaling in Cardiac Regeneration

Award Number: R01HL127717
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2016
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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Hippo and Wnt Signaling in Cardiac Regeneration - This R01 application will investigate a novel signaling pathway, the Hippo pathway, in mammalian heart regeneration. The long-term goal is to develop new treatments for patients with heart failure by generating new cardiomyocytes in the adult heart. The objectives of this application are to gain insight into molecular properties of cardiac tissue that are regulated by Hippo signaling. The central hypothesis is that Hippo signaling is a negative regulatory pathway that prevents cardiomyocyte regeneration in the adult mammalian heart. The specific aims are to determine whether the Hippo and Wnt pathways regulate adult heart repair in a manner similar to the interaction in neonatal hearts. To determine whether an autonomous Wnt Hippo interaction occurs in heart muscle nuclei to control important genes and to investigate whether Hippo functions in a reversible manner. The project is conceptually and technically innovative. Concepts to be tested include new ideas in cardiomyocyte biology and cutting edge genome editing and interrogation technologies to address hypotheses. The significance is high because there are no treatments for heart failure due to cardiomyocyte loss. Devising ways to generate new cardiomyocytes is highly significant.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$293 )
2025	2023	TEXAS HEART INSTITUTE	6770 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	8	5/6/2025	NON-COMPETING CONTINUATION	-$293
														Subtotal = -$293

Issue Date FY: 2023 ( Subtotal = $588,686 )
2023	2023	TEXAS HEART INSTITUTE	6770 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	001	8	3/15/2023	NON-COMPETING CONTINUATION	$58,869
2023	2023	TEXAS HEART INSTITUTE	6770 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	8	1/2/2023	NON-COMPETING CONTINUATION	$529,817
														Subtotal = $588,686

Issue Date FY: 2022 ( Subtotal = $588,686 )
2022	2022	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	001	7	6/29/2022	NON-COMPETING CONTINUATION	$58,869
2022	2022	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	7	1/14/2022	NON-COMPETING CONTINUATION	$529,817
														Subtotal = $588,686

Issue Date FY: 2021 ( Subtotal = $588,686 )
2021	2021	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	002	6	5/24/2021	NON-COMPETING CONTINUATION	$58,869
2021	2021	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	6	1/23/2021	NON-COMPETING CONTINUATION	$529,817
2021	2019	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	001	4	2/20/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $588,686

Issue Date FY: 2020 ( Subtotal = $588,687 )
2020	2020	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	5	11/27/2019	COMPETING CONTINUATION	$588,687
														Subtotal = $588,687

Issue Date FY: 2019 ( Subtotal = $499,306 )
2019	2019	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	4	12/18/2018	NON-COMPETING CONTINUATION	$499,306
														Subtotal = $499,306

Issue Date FY: 2018 ( Subtotal = $499,306 )
2018	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	001	3	7/6/2018	NON-COMPETING CONTINUATION	$9,987
2018	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	3	12/8/2017	NON-COMPETING CONTINUATION	$489,319
														Subtotal = $499,306

Issue Date FY: 2017 ( Subtotal = $502,016 )
2017	2017	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	2	12/12/2016	NON-COMPETING CONTINUATION	$502,016
														Subtotal = $502,016

Issue Date FY: 2016 ( Subtotal = $507,968 )
2016	2016	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	000	1	1/14/2016	NEW	$507,968
														Subtotal = $507,968

Grand Total All Awards = $4,363,048

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Hippo and Wnt Signaling in Cardiac Regeneration

Award Number: R01HL127717

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2016

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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