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Geometric Surrogates for Clinical Management of Abdominal Aortic Aneurysms

Award Number: R01HL121293
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2021

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Geometric Surrogates for Clinical Management of Abdominal Aortic Aneurysms - DESCRIPTION (provided by applicant): This proposal will investigate the following hypothesis: that the quantification of geometric surrogates, which predict the ensuing peak wall rupture risk index (PWRRI), will provide an improved estimate of aneurysm rupture risk compared to the clinical standard of maximum aneurysm diameter. We thus propose the highly innovative use of both radiological and non-radiological clinical imaging to develop a computational tool that can assess AAA risk of rupture with greater accuracy than the current clinical standard. Such a tool will allow the accurate quantification of individual AAA geometry to achieve the main goal of the study, which is to identify the patient-specific AAA geometry characteristics that are surrogates for patient-specific PWRRI. In the proposed approach, we will first compute a truly individualized PWRRI based on an innovative method called image-based Vascular Mechanical Characterization technology (iV-MeCh). The geometry characteristics highly correlated with PWRRI will be considered the surrogates of this biomechanics-based index. A second phase of the study will be the validation of the surrogates with actual clinical outcomes, which will yield the accurate predictors of rupture. This approach, devoid of complex finite element modeling and based on a fast, nearly automated computational tool for geometry quantification, would provide an exceptional rationale for the need for surgical intervention and be of major clinical significance. Therefore, the following specific aims are to be completed during the project period to address the aforementioned hypothesis: (1) Validate iV-MeCh for estimating patient-specific spatio-temporal AAA wall stress; (2) Calculate individual PWRRI using iV-MeCh for high and low risk of rupture AAA; (3) Identify the individual geometry characteristics that are surrogates of PWRRI; and (4) Assess the clinical significance of geometric surrogates for the prediction of AAA rupture risk. The primary outcome of this research will be the ability to disambiguate or demystify rupture risk in AAA for which the standard of care (maximum diameter) is not an accurate metric for assessing their at-risk condition. The geometric surrogates of PWRRI are hypothesized to reduce false positives and false negatives compared to the conventional maximum diameter cut-off for recommending elective repair. In addition, PWRRI is predicted by means of a new, novel technique (iV-MeCh), which estimates wall stress in aneurysms by means of non-radiological clinical imaging and without the use of constitutive soft tissue mechanics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$8,056 )
2022	2018	UNIVERSITY OF TEXAS AT SAN ANTONIO, THE	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	001	4	6/29/2022	NON-COMPETING CONTINUATION	-$8,056
2022	2017	UNIVERSITY OF TEXAS AT SAN ANTONIO, THE	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	000	3	6/29/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = -$8,056

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	UNIVERSITY OF TEXAS AT SAN ANTONIO, THE	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	000	4	8/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	UNIVERSITY OF TEXAS AT SAN ANTONIO, THE	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	000	4	4/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $398,926 )
2018	2018	UNIVERSITY OF TEXAS AT SAN ANTONIO, THE	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	001	4	7/23/2018	NON-COMPETING CONTINUATION	$7,979
2018	2018	UNIVERSITY OF TEXAS AT SAN ANTONIO, THE	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	000	4	3/30/2018	NON-COMPETING CONTINUATION	$390,947
														Subtotal = $398,926

Issue Date FY: 2017 ( Subtotal = $398,926 )
2017	2017	UNIVERSITY OF TEXAS AT SAN ANTONIO	ONE UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	000	3	4/1/2017	NON-COMPETING CONTINUATION	$398,926
														Subtotal = $398,926

Issue Date FY: 2016 ( Subtotal = $474,831 )
2016	2016	UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	000	2	3/28/2016	NON-COMPETING CONTINUATION	$474,831
														Subtotal = $474,831

Issue Date FY: 2015 ( Subtotal = $514,370 )
2015	2015	UNIVERSITY OF TEXAS AT SAN ANTONIO	1 UTSA CIRCLE	SAN ANTONIO	TX	78249	BEXAR	USA	Cardiovascular Diseases Research	000	1	3/26/2015	NEW	$514,370
														Subtotal = $514,370

Grand Total All Awards = $1,778,997

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Geometric Surrogates for Clinical Management of Abdominal Aortic Aneurysms

Award Number: R01HL121293

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2021

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