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Development and function in mucociliary epithelia

Award Number: R01HL117164
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2013
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Development and function in mucociliary epithelia - Abstract: The mucociliary epithelium plays a key role in both normal and pathological airway biology, as it provides the first line of defense against inhaled agents. Defects in ciliary beating in multiciliated cells (MCCs) in the airway contribute to the progression of both genetic and acquired airway diseases. Here, we will study the molecular mechanisms controlling development and function of MCCs. The motor proteins that drive ciliary beating are assembled in the cytoplasm, and under the previous version of this award, we discovered a novel organelle in which these motors are concentrated with various factors that direct their assembly. The first Aim of this project will explore the hierarchy of interaction among proteins in these novel organelles; the second will explore the mechanisms by which motors are transported into cilia, and the third will use large-sale proteomic approaches to identify novel protein-protein interactions important for motor assembly and function. By rapidly determining the functions of several new protein involved in distinct processes in MCC development, the Aims in this proposal will provide critical new depth to our understanding of these essential cell. Moreover, by linking these the disparate processes in MCCs, the experiments here will add crucial new breadth to our understanding as well. Impact: Experiments proposed here will lead to a more detailed understanding of the cell biology and genetics of MCCs and ciliary beating. The results will aid in the development of regenerative therapies aimed at repairing or restoring damaged tissue and improving mucus clearance in patients with airway disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $497,473 )
2025	2025	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	002	11	6/28/2025	NON-COMPETING CONTINUATION	$497,473
2025	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	001	9	2/12/2025	COMPETING CONTINUATION	$12,962
2025	2021	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	000	8	2/12/2025	NON-COMPETING CONTINUATION	-$12,962
														Subtotal = $497,473

Issue Date FY: 2024 ( Subtotal = $389,523 )
2024	2024	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	000	10	5/29/2024	NON-COMPETING CONTINUATION	$389,523
														Subtotal = $389,523

Issue Date FY: 2023 ( Subtotal = $397,473 )
2023	2023	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	001	9	6/9/2023	COMPETING CONTINUATION	$397,473
2023	2021	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	000	8	2/16/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $397,473

Issue Date FY: 2021 ( Subtotal = $385,035 )
2021	2021	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	000	8	3/5/2021	NON-COMPETING CONTINUATION	$385,035
														Subtotal = $385,035

Issue Date FY: 2020 ( Subtotal = $385,035 )
2020	2020	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	000	7	3/6/2020	NON-COMPETING CONTINUATION	$385,035
														Subtotal = $385,035

Issue Date FY: 2019 ( Subtotal = $385,035 )
2019	2019	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	000	6	3/11/2019	NON-COMPETING CONTINUATION	$385,035
														Subtotal = $385,035

Issue Date FY: 2018 ( Subtotal = $379,385 )
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	003	5	6/14/2018	COMPETING CONTINUATION	$85,101
2018	2018	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	001	5	2/23/2018	COMPETING CONTINUATION	$379,385
2018	2016	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	002	4	6/14/2018	EXTENSION WITH OR WITHOUT FUNDS	-$85,101
2018	2016	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	000	4	2/22/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $379,385

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	001	4	10/27/2016	EXTENSION WITH OR WITHOUT FUNDS	$80,470
2017	2015	UNIVERSITY OF TEXAS AT AUSTIN	110 INNER CAMPUS DR, MN 13	AUSTIN	TX	78712	TRAVIS	USA	Lung Diseases Research	000	3	10/27/2016	NON-COMPETING CONTINUATION	-$80,470
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $386,250 )
2016	2016	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Lung Diseases Research	000	4	5/27/2016	EXTENSION WITH OR WITHOUT FUNDS	$386,250
														Subtotal = $386,250

Issue Date FY: 2015 ( Subtotal = $380,456 )
2015	2015	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Lung Diseases Research	000	3	6/26/2015	NON-COMPETING CONTINUATION	$380,456
														Subtotal = $380,456

Issue Date FY: 2014 ( Subtotal = $378,525 )
2014	2014	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Lung Diseases Research	000	2	5/31/2014	NON-COMPETING CONTINUATION	$378,525
														Subtotal = $378,525

Issue Date FY: 2013 ( Subtotal = $367,611 )
2013	2013	UNIVERSITY OF TEXAS AT AUSTIN	P.O. BOX 7159	AUSTIN	TX	78713	TRAVIS	USA	Lung Diseases Research	000	1	8/5/2013	NEW	$367,611
														Subtotal = $367,611

Grand Total All Awards = $4,331,801

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Development and function in mucociliary epithelia

Award Number: R01HL117164

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2013

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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