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Noradrenergic A7 neurons and Upper Airway Motor Control

Award Number: R01HL116845
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2013
PERIOD OF PERFORMANCE END DATE: 04/30/2018

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Noradrenergic A7 neurons and Upper Airway Motor Control - DESCRIPTION (provided by applicant): Obstructive Sleep Apnea (OSA) is a growing health problem which affects almost 5% of the adult population. Due to airway obstruction and repetitive waking during sleep, OSA patients have excessive daytime sleepiness and a diminished quality of life. OSA is associated with hypertension, diabetes, coronary artery disease, strokes and congestive heart failure. The treatment options for OSA are limited to surgery and the use of oral appliances; no effective pharmacological therapy is available. Hypoglossal motoneurons play a critical role in pathology of the OSA because they innervate the muscles of the tongue that are important for maintaining airway patency. A decrease in their activity during sleep and especially rapid eye movement (REM) sleep is the main cause of airway obstruction in OSA. Therefore, complete understanding of the neuronal network that controls activity of hypoglossal motoneurons during sleep and wakefulness may help to develop pharmacological strategies to treat OSA. In the proposed project, we will study the role of noradrenergic A7 neurons in the neuronal network that controls activity of hypoglossal motoneurons during the natural sleep-wake cycle using a novel animal model. We will obtain data regarding behavior of A7 neurons during states of sleep and wakefulness, their downstream projections and their contribution to the mechanisms of the depression of hypoglossal motoneurons excitability during non-REM and REM sleep. Obtained information will advance our understanding of the neuronal network and neurochemical mechanisms that control state-dependent activity of hypoglossal motoneurons and provide a foundation for developing effective pharmacological treatments for OSA


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE, INC.	11301 WILLSHIRE BLVD BLDG 114 RM 218	LOS ANGELES	CA	90073	LOS ANGELES	USA	Lung Diseases Research	000	4	7/27/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE, INC.	11301 WILLSHIRE BLVD BLDG 114 RM 218	LOS ANGELES	CA	90073	LOS ANGELES	USA	Lung Diseases Research	001	4	12/16/2016	EXTENSION WITH OR WITHOUT FUNDS	$10,000
2017	2015	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE, INC.	11301 WILLSHIRE BLVD BLDG 114 RM 218	LOS ANGELES	CA	90073	LOS ANGELES	USA	Lung Diseases Research	000	3	12/16/2016	NON-COMPETING CONTINUATION	-$10,000
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $307,500 )
2016	2016	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Lung Diseases Research	000	4	4/19/2016	EXTENSION WITH OR WITHOUT FUNDS	$307,500
														Subtotal = $307,500

Issue Date FY: 2015 ( Subtotal = $302,887 )
2015	2015	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Lung Diseases Research	000	3	4/23/2015	NON-COMPETING CONTINUATION	$302,887
														Subtotal = $302,887

Issue Date FY: 2014 ( Subtotal = $301,350 )
2014	2014	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Lung Diseases Research	000	2	5/5/2014	NON-COMPETING CONTINUATION	$301,350
														Subtotal = $301,350

Issue Date FY: 2013 ( Subtotal = $292,740 )
2013	2013	BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE	P.O. BOX 25027	LOS ANGELES	CA	90025	LOS ANGELES	USA	Lung Diseases Research	000	1	5/24/2013	NEW	$292,740
														Subtotal = $292,740

Grand Total All Awards = $1,204,477

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Noradrenergic A7 neurons and Upper Airway Motor Control

Award Number: R01HL116845

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2013

PERIOD OF PERFORMANCE END DATE: 04/30/2018

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