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Improved ventilation of the edematous lung

Award Number: R01HL113577
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2013
PERIOD OF PERFORMANCE END DATE: 09/23/2023

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Improved ventilation of the edematous lung - Project Summary In the acute respiratory distress syndrome (ARDS), inflammatory lung injury increases alveolar-capillary barrier permeability. Vascular liquid floods the airspace of the lungs and causes pulmonary edema. The airspace flooding pattern is spatially heterogeneous. Patients with ARDS are treated by mechanical ventilation, which improves gas exchange but causes additional mechanical injury to the lungs that escalates over time. In particular, alveolar septa located between aerated and flooded alveoli are a site of stress concentration and the magnitude of the stress concentration is proportional to the surface tension at the air-liquid interface in flooded alveoli. Mechanical ventilation cyclically increases surface tension, thus exacerbates the stress concentrations and causes injury in the form of a sustained increase in surface tension. The sustained increase in surface tension makes mechanical ventilation yet more injurious. Thus ventilation injury escalates, with positive feedback, over time. Working in a high tidal volume lung injury model in rats, we aim to test a surface tension-lowering compound as a means of reducing the escalation of ventilation injury and to investigate the mechanism through which the compound acts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$123,642 )
2024	2021	THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY	ONE CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	9	5/10/2024	NON-COMPETING CONTINUATION	-$123,642
														Subtotal = -$123,642

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY	1 CASTLEPOINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	9	6/8/2023	NON-COMPETING CONTINUATION	$0
2023	2021	THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOGY	1 CASTLEPOINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	001	9	9/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $444,595 )
2021	2021	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	9	5/27/2021	NON-COMPETING CONTINUATION	$444,595
														Subtotal = $444,595

Issue Date FY: 2020 ( Subtotal = $444,595 )
2020	2020	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	8	5/29/2020	NON-COMPETING CONTINUATION	$444,595
														Subtotal = $444,595

Issue Date FY: 2019 ( Subtotal = $444,595 )
2019	2019	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	002	7	6/24/2019	NON-COMPETING CONTINUATION	$444,595
2019	2018	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	001	6	6/10/2019	COMPETING CONTINUATION	$130,984
2019	2017	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	5	6/10/2019	NON-COMPETING CONTINUATION	-$130,984
														Subtotal = $444,595

Issue Date FY: 2018 ( Subtotal = $444,595 )
2018	2018	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	6	1/30/2018	COMPETING CONTINUATION	$444,595
														Subtotal = $444,595

Issue Date FY: 2017 ( Subtotal = $312,216 )
2017	2017	STEVENS INSTITUTE OF TECHNOLOGY (INC)	1 CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	5	1/5/2017	NON-COMPETING CONTINUATION	$312,216
														Subtotal = $312,216

Issue Date FY: 2016 ( Subtotal = $312,216 )
2016	2016	STEVENS INSTITUTE OF TECHNOLOGY	CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	4	1/19/2016	EXTENSION WITH OR WITHOUT FUNDS	$307,532
2016	2016	STEVENS INSTITUTE OF TECHNOLOGY	CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	001	4	2/1/2016	EXTENSION WITH OR WITHOUT FUNDS	$4,684
														Subtotal = $312,216

Issue Date FY: 2015 ( Subtotal = $307,532 )
2015	2015	STEVENS INSTITUTE OF TECHNOLOGY	CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	3	12/20/2014	NON-COMPETING CONTINUATION	$280,994
2015	2015	STEVENS INSTITUTE OF TECHNOLOGY	CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	001	3	2/23/2015	NON-COMPETING CONTINUATION	$26,538
														Subtotal = $307,532

Issue Date FY: 2014 ( Subtotal = $305,972 )
2014	2014	STEVENS INSTITUTE OF TECHNOLOGY	CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	001	2	2/28/2014	NON-COMPETING CONTINUATION	$24,978
2014	2014	STEVENS INSTITUTE OF TECHNOLOGY	CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	2	1/6/2014	NON-COMPETING CONTINUATION	$280,994
														Subtotal = $305,972

Issue Date FY: 2013 ( Subtotal = $312,216 )
2013	2013	STEVENS INSTITUTE OF TECHNOLOGY	CASTLE POINT ON HUDSON	HOBOKEN	NJ	07030	HUDSON	USA	Lung Diseases Research	000	1	2/12/2013	NEW	$312,216
														Subtotal = $312,216

Grand Total All Awards = $3,204,890

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Improved ventilation of the edematous lung

Award Number: R01HL113577

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2013

PERIOD OF PERFORMANCE END DATE: 09/23/2023

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