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CVD in American Indians The Dakota Field Center

Award Number: R01HL109315
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2013
PERIOD OF PERFORMANCE END DATE: 11/30/2019

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CVD in American Indians The Dakota Field Center - DESCRIPTION (provided by applicant): The Strong Heart Study (SHS) of two unique American Indian (AI) cohorts (4549 adults, aged 45 to 74 and 3838 �15 yrs. from 94 families) constitutes an unequalled and irreplaceable national resource. The proposed studies will elucidate the genetics and early pathophysiology of diabetic CVD and also address health disparities experienced by populations with high rates of diabetes and CVD. Very high rates of obesity and diabetes, especially among younger SHS participants, herald a pending epidemic of CVD, making them the ideal population in which to examine these processes. Measures of CVD, preclinical CVD, biomarkers, and genetic findings have provided valuable pathogenetic insights related to the etiology of CVD; the proposed investigations will take maximal advantage of this solid foundation and add innovative new measures. Our Aims: The identification of genetic variants affecting risk of obesity, diabetes, preclinical CVD, and CVD events, aided by new genomic technologies. We will use genomics techniques for SNP discovery and subsequent statistical analysis of functionality in regions known to contain genes of interest. Transcriptional profiling of RNA concurrent with a liver/abdominal MRI will be used to relate expression of genes and gene networks to CVD etiology. New biological measurements during a re-examination of the large family-based cohort will expand knowledge of pre-clinical stages of obesity and diabetes associated CVD. Novel phenotypes defined by MRI of the abdomen (for fat deposition in liver and adipose depots) will elucidate the etiology of preclinical disease in younger persons. Measures of central blood pressure (by applanation tonometry), heart rate variability and abdominal aortic size will broaden our understanding of CVD in association with obesity and diabetes. Measures of physiologic and behavioral risk factors, such as demographics, reproductive history, socioeconomic status, tobacco use, alcohol, diet, mental health indicators, and physical activity (by accelerometer) will add additional key phenotypes. Continuing mortality and morbidity surveillance of these cohorts will provide increased power in understanding how obesity and diabetes lead to strokes and heart failure in later life. Secular trends, life expectancy, the effects of renal disease on preclinical CVD, and the role of preclinical measures in predicting CVD endpoints will be explored. Thus, the proposed investigations will lead to new understanding of CVD and preclinical and diabetic CVD as well as improvements in clinical practice.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2017	MISSOURI BREAKS INDUSTRIES RESEARCH, INC.	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Cardiovascular Diseases Research	002	5	4/28/2020	NON-COMPETING CONTINUATION	$0
2020	2016	MISSOURI BREAKS INDUSTRIES RESEARCH, INC.	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Cardiovascular Diseases Research	001	4	3/25/2020	EXTENSION WITH OR WITHOUT FUNDS	$225,064
2020	2015	MISSOURI BREAKS INDUSTRIES RESEARCH, INC.	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Cardiovascular Diseases Research	000	3	3/25/2020	NON-COMPETING CONTINUATION	-$225,064
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2017	MISSOURI BREAKS INDUSTRIES RESEARCH, INC.	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Cardiovascular Diseases Research	000	5	1/11/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $97,019 )
2018	2018	MISSOURI BREAKS INDUSTRIES RESEARCH, INC.	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Cardiovascular Diseases Research	000	5	1/20/2018	SUPPLEMENT FOR EXPANSION	$97,019
														Subtotal = $97,019

Issue Date FY: 2017 ( Subtotal = $344,313 )
2017	2017	MISSOURI BREAKS INDUSTRIES RESEARCH INC	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Cardiovascular Diseases Research	001	5	5/25/2017	NON-COMPETING CONTINUATION	$341,724
2017	2017	MISSOURI BREAKS INDUSTRIES RESEARCH INC	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Cardiovascular Diseases Research	000	4	12/16/2016	SUPPLEMENT FOR EXPANSION	$2,589
														Subtotal = $344,313

Issue Date FY: 2016 ( Subtotal = $331,052 )
2016	2016	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	4	5/27/2016	EXTENSION WITH OR WITHOUT FUNDS	$331,052
														Subtotal = $331,052

Issue Date FY: 2015 ( Subtotal = $326,085 )
2015	2015	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	3	5/8/2015	NON-COMPETING CONTINUATION	$326,085
														Subtotal = $326,085

Issue Date FY: 2014 ( Subtotal = $324,430 )
2014	2014	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	2	5/7/2014	NON-COMPETING CONTINUATION	$324,430
														Subtotal = $324,430

Issue Date FY: 2013 ( Subtotal = $503,843 )
2013	2013	MISSOURI BREAKS RESEARCH, INC	HCR 64 BOX 52	TIMBER LAKE	SD	57656	DEWEY	USA	Cardiovascular Diseases Research	000	1	5/23/2013	NEW	$503,843
														Subtotal = $503,843

Grand Total All Awards = $1,926,742

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CVD in American Indians The Dakota Field Center

Award Number: R01HL109315

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2013

PERIOD OF PERFORMANCE END DATE: 11/30/2019

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