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Translational Study of Cardiac Dysfunction

Award Number: R01HL085727
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract Atrial fibrillation (AF) represents one of the most common arrhythmias clinically and is associated with a significant increase in morbidity and mortality, yet, current treatment paradigms remain inadequate. Treatment with conventional antiarrhythmic drugs generally carries a high risk of proarrhythmia. Moreover, prevalence of AF is increasing due to the aging population. We were the first to demonstrate beneficial effects of a novel class of anti-inflammatory agent, soluble epoxide hydrolase (sEH) inhibitors, in clinically relevant models of cardiac hypertrophy and failure. Treatment with sEH inhibitors (sEHIs) results in the prevention of ventricular myocyte hypertrophy and electrical remodeling in pressure overload and MI models. During the last funding cycle, we demonstrate that treatment with sEHIs prevents cardiac fibroblast (CF) proliferation, fibrosis, adverse cardiac remodeling, and AF. These results demonstrate broader salutary effects in cardiac remodeling (not limited to myocyte hypertrophy alone) of this novel class of compounds. The goal of the competing renewal is to test the hypothesis that an increase in the level of endogenous EETs by sEHIs represents a completely unexplored avenue to modify atrial fibrosis by reducing CF proliferation and activation. The proposal represents a bench-to-bedside multidisciplinary study to determine the mechanism and efficacy of using sEHIs for the treatment of AF.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	12	1/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $678,672 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	001	12	6/29/2022	NON-COMPETING CONTINUATION	$67,867
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	12	1/31/2022	NON-COMPETING CONTINUATION	$610,805
														Subtotal = $678,672

Issue Date FY: 2021 ( Subtotal = $678,672 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	11	2/4/2021	NON-COMPETING CONTINUATION	$678,672
														Subtotal = $678,672

Issue Date FY: 2020 ( Subtotal = $678,672 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	10	1/24/2020	NON-COMPETING CONTINUATION	$678,672
														Subtotal = $678,672

Issue Date FY: 2019 ( Subtotal = $678,491 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	003	9	6/21/2019	COMPETING CONTINUATION	$1,241
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	9	4/15/2019	COMPETING CONTINUATION	$678,491
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	005	9	9/6/2019	COMPETING CONTINUATION	$1,000
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	007	9	9/23/2019	COMPETING CONTINUATION	-$117
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	001	9	6/5/2019	COMPETING CONTINUATION	$0
2019	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	004	8	9/6/2019	EXTENSION WITH OR WITHOUT FUNDS	-$1,000
2019	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	006	8	9/23/2019	EXTENSION WITH OR WITHOUT FUNDS	$117
2019	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	002	8	6/21/2019	EXTENSION WITH OR WITHOUT FUNDS	-$1,241
														Subtotal = $678,491

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	8	1/23/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $385,000 )
2016	2016	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	8	2/25/2016	EXTENSION WITH OR WITHOUT FUNDS	$385,000
														Subtotal = $385,000

Issue Date FY: 2015 ( Subtotal = $379,225 )
2015	2015	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	7	2/12/2015	NON-COMPETING CONTINUATION	$379,225
														Subtotal = $379,225

Issue Date FY: 2014 ( Subtotal = $377,300 )
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	000	6	2/14/2014	NON-COMPETING CONTINUATION	$346,500
2014	2014	UNIVERSITY OF CALIFORNIA	1850 RESEARCH PARK DRIVE	DAVIS	CA	95618	YOLO	USA	Cardiovascular Diseases Research	001	6	3/20/2014	NON-COMPETING CONTINUATION	$30,800
														Subtotal = $377,300

Issue Date FY: 2013 ( Subtotal = $366,520 )
2013	2013	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	5	5/29/2013	COMPETING CONTINUATION	$366,520
														Subtotal = $366,520

Issue Date FY: 2011 ( Subtotal = $380,000 )
2011	2011	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	4	1/27/2011	NON-COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2010 ( Subtotal = $380,000 )
2010	2010	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	3	1/20/2010	NON-COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2009 ( Subtotal = $380,000 )
2009	2009	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	2	1/30/2009	NON-COMPETING CONTINUATION	$380,000
														Subtotal = $380,000

Issue Date FY: 2008 ( Subtotal = $380,000 )
2008	2008	UNIVERSITY OF CALIFORNIA	1441 RESEARCH PARK DRIVE	DAVIS	CA	95616	YOLO	USA	Cardiovascular Diseases Research	000	1	1/28/2008	NEW	$380,000
														Subtotal = $380,000

Grand Total All Awards = $5,742,552

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Translational Study of Cardiac Dysfunction

Award Number: R01HL085727

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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