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OSTEOPROTEGERIN AND OSTEOPONTIN IN AORTIC ANEURYSM

Award Number: R01HL080010
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2005
PERIOD OF PERFORMANCE END DATE: 05/31/2010

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OSTEOPROTEGERIN AND OSTEOPONTIN IN AORTIC ANEURYSM - DESCRIPTION (provided by applicant): Weakening and dilation of the main abdominal artery (aortic aneurysm, AAA) affects 5-10% of men and 1% of women aged over 60 years. The weakening process is usually progressive and without surgical repair the artery can burst usually leading to death. Despite improved medical treatment of artery disease the incidence of this problem is increasing. At present no medication has been clearly shown to halt or slow the artery weakening in humans. The aortic weakening results from inflammation, protein degrading enzymes and loss of vascular smooth muscle cells (VSMC). In this study we investigate the role of two calcium-controlling proteins, osteoprotegerin (OPG) and osteopontin (OPN), in human artery weakening. These proteins are of particular interest because preliminary human, animal and cell studies suggest they may be of critical importance in AAA. The role of OPG and OPN in AAA development and progression will be assessed by a combination of human, animal and cell culture experiments. The effect of variation in the OPG and OPN genes on AAA development and progression will be assessed by genetic analysis of DNA from 4045 participants in the Western Australian AAA study. The influence of OPG and OPN on inflammation, protein degrading enzymes and VSMC loss will be studied in cell culture and an animal model of AAA. Finally, two potential medical treatments for AAA will be assessed as to their effect on OPG and OPN utilizing cell culture and animal studies. Understanding the role of these calcium-controlling proteins in artery weakness and how drug therapy can interfere in these effects is an important step in the development of new treatment for aortic aneurysm.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $256,009 )
2009	2009	JAMES COOK UNIVERSITY OF NO QUEENSLAND	TOWNSVILLE 4811	TOWNSVILLE				AUS	Cardiovascular Diseases Research	000	5	6/15/2009	NON-COMPETING CONTINUATION	$256,009
														Subtotal = $256,009

Issue Date FY: 2008 ( Subtotal = $256,009 )
2008	2008	JAMES COOK UNIVERSITY OF NO QUEENSLAND	TOWNSVILLE 4811	TOWNSVILLE				AUS	Cardiovascular Diseases Research	000	4	5/14/2008	NON-COMPETING CONTINUATION	$256,009
														Subtotal = $256,009

Issue Date FY: 2007 ( Subtotal = $256,009 )
2007	2007	JAMES COOK UNIVERSITY OF NO QUEENSLAND	TOWNSVILLE 4811	TOWNSVILLE				AUS	Cardiovascular Diseases Research	000	3	5/23/2007	NON-COMPETING CONTINUATION	$256,009
														Subtotal = $256,009

Issue Date FY: 2006 ( Subtotal = $263,655 )
2006	2006	JAMES COOK UNIVERSITY OF NO QUEENSLAND	TOWNSVILLE 4811	TOWNSVILLE				AUS	Cardiovascular Diseases Research	000	2	5/24/2006	NON-COMPETING CONTINUATION	$263,655
														Subtotal = $263,655

Issue Date FY: 2005 ( Subtotal = $270,000 )
2005	2005	JAMES COOK UNIVERSITY OF NO QUEENSLAND	TOWNSVILLE 4811	TOWNSVILLE				AUS	Cardiovascular Diseases Research	000	1	5/25/2005	NEW	$270,000
														Subtotal = $270,000

Grand Total All Awards = $1,301,682

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OSTEOPROTEGERIN AND OSTEOPONTIN IN AORTIC ANEURYSM

Award Number: R01HL080010

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2005

PERIOD OF PERFORMANCE END DATE: 05/31/2010

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