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GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION

Award Number: R01HL069122
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2001
PERIOD OF PERFORMANCE END DATE: 08/31/2005

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GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION - DESCRIPTION (provided by applicant): Hypertension is a major cause of cardiovascular diseases, with damage to target organs constituting the principal source of morbidity and mortality. In addition to the health burden, these problems also translate into huge costs for the Medicare budget. There is evidence that damage to target organs does not correlate well with the severity of hypertension, but might rather be explained by susceptibility factors, including genetic ones. Our long-term objectives are to identify genes linked to two important complications of hypertension: (1) left ventricular hypertrophy (L.H.), and (2) hypertension-induced renal damage (HIRD). Since such complex disease manifestations are typically controlled by several genes that have weak effects, it is difficult to detect such genes directly in humans. One alternative is to use animal models of such conditions and, after finding candidate genes, to extrapolate these findings to humans. We will therefore use genetically pure line of rodents that constitute models for L.H. and HIRD, and cross them to the other inbred strains to generate genetic segregating populations. The progeny of these crosses will be extensively phenotyped and genotyped in order identify quantitative trait loci (QTL) linked to either L.H. or HIRD. Subsequently, congenic lines will be generated to: (1) validate the effects of the QTLs, and (2) provide models to perform experiments aimed at identifying candidate mechanisms and candidate genes linked to the trait of interest.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $261,109 )
2004	2004	CLINICAL RESEARCH INSTITUTE OF MONTREAL	110 Pine Ave. W.	MONTREAL				CAN	Cardiovascular Diseases Research	000	4	8/30/2004	NON-COMPETING CONTINUATION	$261,109
														Subtotal = $261,109

Issue Date FY: 2003 ( Subtotal = $255,629 )
2003	2003	CLINICAL RESEARCH INSTITUTE OF MONTREAL	110 Pine Ave. W.	MONTREAL				CAN	Cardiovascular Diseases Research	000	3	9/5/2003	NON-COMPETING CONTINUATION	$255,629
														Subtotal = $255,629

Issue Date FY: 2002 ( Subtotal = $249,030 )
2002	2002	CLINICAL RESEARCH INSTITUTE OF MONTREAL	110 Pine Ave. W.	MONTREAL				CAN	Cardiovascular Diseases Research	000	2	9/19/2002	NON-COMPETING CONTINUATION	$249,030
														Subtotal = $249,030

Issue Date FY: 2001 ( Subtotal = $289,254 )
2001	2001	CLINICAL RESEARCH INSTITUTE OF MONTREAL	110 Pine Ave. W.	MONTREAL				CAN	Cardiovascular Diseases Research	000	1	9/24/2001	NEW	$289,254
														Subtotal = $289,254

Grand Total All Awards = $1,055,022

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GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION

Award Number: R01HL069122

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2001

PERIOD OF PERFORMANCE END DATE: 08/31/2005

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