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NEW CVD RISK FACTORS FOR LOWERED CONGITIVE FUNCTIONING

Award Number: R01HL067358
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2001
PERIOD OF PERFORMANCE END DATE: 03/31/2006

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NEW CVD RISK FACTORS FOR LOWERED CONGITIVE FUNCTIONING - DESCRIPTION: Arterial hypertension and high blood pressure (BP) are major risk factors for cardiovascular disease (CVD) and stroke; they are also risk factors for lowered cognitive functioning. Except for diabetes, there have been comparatively few studies of other common risk factors, particularly with regard to interrelationships among risk factors which may adversely affect cognitive ability. This study is concerned with associations between cognitive functioning and three major CVD risk factors: (1) BP, (2) high total plasma homocysteine (tHcy), and (3) ApoE e4 genotype. Although high BP is a well-established risk factor for lowered cognitive functioning, tHcy and ApoE e4 are relatively unexplored variables with respect to cognitive functioning. A major objective is to investigate the individual, cumulative, and synergistic effects of BP, tHcy levels, and ApoE e4 genotype on cognitive functioning over a broad range of cognitive abilities. Three secondary, but important, objectives are to determine: (1) the extent to which the adverse influence of these three CYD risk factors on cognitive functioning is affected by the presence of coexisting CVD risk factors (e.g., cigarette smoking); (2) the cumulative impact of multiple risk factors on cognitive functioning; (3) the extent to which age effects on cognitive functioning are attenuated by adjustment for BP, tHey, ApoE genotype, and other CVD risk factors. The study makes use of existing data from a large longitudinal study of hypertension and cognitive functioning. Additionally, important new information about relations among tHey, ApoE, and BP will be obtained by calling back the longitudinal subjects for additional studies of cognitive functioning and making use of concurrent, prospective, and retrospective analyses.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2005 ( Subtotal = $450,694 )
2005	2005	UNIVERSITY OF MAINE, PORTLAND-GORHAM	96 FALMOUTH STREET	PORTLAND	ME	04103	CUMBERLAND	USA	Cardiovascular Diseases Research	000	5	2/24/2005	NON-COMPETING CONTINUATION	$450,694
														Subtotal = $450,694

Issue Date FY: 2004 ( Subtotal = $472,968 )
2004	2004	UNIVERSITY OF MAINE, PORTLAND-GORHAM	96 FALMOUTH STREET	PORTLAND	ME	04103	CUMBERLAND	USA	Cardiovascular Diseases Research	000	4	2/23/2004	NON-COMPETING CONTINUATION	$472,968
														Subtotal = $472,968

Issue Date FY: 2003 ( Subtotal = $459,194 )
2003	2003	UNIVERSITY OF MAINE, PORTLAND-GORHAM	96 FALMOUTH STREET	PORTLAND	ME	04103	CUMBERLAND	USA	Cardiovascular Diseases Research	000	3		NON-COMPETING CONTINUATION	$459,194
														Subtotal = $459,194

Issue Date FY: 2002 ( Subtotal = $445,819 )
2002	2002	UNIVERSITY OF MAINE, PORTLAND-GORHAM	96 FALMOUTH STREET	PORTLAND	ME	04103	CUMBERLAND	USA	Cardiovascular Diseases Research	000	2	3/8/2002	NON-COMPETING CONTINUATION	$445,819
														Subtotal = $445,819

Issue Date FY: 2001 ( Subtotal = $443,594 )
2001	2001	UNIVERSITY OF MAINE, PORTLAND-GORHAM	96 FALMOUTH STREET	PORTLAND	ME	04103	CUMBERLAND	USA	Cardiovascular Diseases Research	000	1	3/16/2001	NEW	$443,594
														Subtotal = $443,594

Grand Total All Awards = $2,272,269

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NEW CVD RISK FACTORS FOR LOWERED CONGITIVE FUNCTIONING

Award Number: R01HL067358

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2001

PERIOD OF PERFORMANCE END DATE: 03/31/2006

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