Monday, November 17, 2025 11/17/2025

GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS

Award Number: R01HL060944
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/1999
PERIOD OF PERFORMANCE END DATE: 12/31/2010

Group Awards By:

View Award Description

GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS - DESCRIPTION (provided by applicant): The IRAS Family Study, initially funded as six linked R01s in 1999, is a multicenter project designed to study the genetic epidemiology of adiposity and glucose homeostasis. The recruitment and phenotyping components have been completed in the three clinical centers. All families were of African-American or Hispanic descent. A total of 132 extended families (1861 subjects) have been studied for measurement of adiposity by abdominal CT scan and glucose homeostasis using the insulin-modified frequently sampledintravenous glucose tolerance test (FSIGT). These investigations have identified substantial genetic contribution to measures of adiposity (visceral and sub-cutaneous fat, BMI and waist circumference) and glucose homeostasis (insulin sensitivity, glucose effectiveness, acute insulin response to glucose, disposition index, fasting glucose and fasting insulin). A 10 cM genome scan of the IRAS Family Study DNA has been completed. Linkage analyses have identified several genomic regions related to adiposity and glucose homeostasis. Several of these signals have been followed-up with fine mapping. This renewal application, entitled Genetics of Adiposity and Glucose Homeostasis, targets the further exploration of genomic regions and positional cloning of genes contributing to variation in adiposity and glucose homeostasis. Positional candidate genes will be identified. We will also re-contact the original cohort to repeat some of the primary phenotypes for measures of change (abdominal CT scan and fasting insulin) and add several important new phenotypes to add depth to our assessment of adiposity and glucose homeostasis (total body fat by DXA and adipocytokines, including adiponectin and soluble TNF-alpha receptors 1 and 2). A panel of nutritional, dietary, and eating behaviors will be assessed in which to study the genetic effects. Using the existing genome scan data and variance-components-based linkage analysis methods, regions of the genome will be detected that contribute to variation in these new phenotypes and in the change phenotypes. The proposed study is unique in its performance of gone discovery for adiposity and glucose homeostasis in a multi-ethnic (non-majority) sample while simultaneously examining the genetic and environmental correlations among these and other metabolic phenotypes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	002	10	9/2/2010	NON-COMPETING CONTINUATION	$0
2010	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	001	10	5/18/2010	NON-COMPETING CONTINUATION	$0
2010	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	000	10	1/20/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $442,677 )
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	004	10	5/26/2009	NON-COMPETING CONTINUATION	$0
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	002	10	4/3/2009	NON-COMPETING CONTINUATION	$44,268
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	003	10	4/20/2009	NON-COMPETING CONTINUATION	$0
2009	2009	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	001	10	1/29/2009	NON-COMPETING CONTINUATION	$398,409
2009	2007	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	000	8	4/20/2009	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $442,677

Issue Date FY: 2008 ( Subtotal = $563,187 )
2008	2008	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	000	9	12/18/2007	NON-COMPETING CONTINUATION	$563,187
														Subtotal = $563,187

Issue Date FY: 2007 ( Subtotal = $690,657 )
2007	2007	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	001	8	7/1/2007	SUPPLEMENT FOR EXPANSION	$100,536
2007	2007	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	000	8	12/20/2006	NON-COMPETING CONTINUATION	$537,134
2007	2007	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	002	8	9/18/2007	SUPPLEMENT FOR EXPANSION	$52,987
														Subtotal = $690,657

Issue Date FY: 2006 ( Subtotal = $682,842 )
2006	2006	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	000	7	12/23/2005	NON-COMPETING CONTINUATION	$682,842
														Subtotal = $682,842

Issue Date FY: 2005 ( Subtotal = $753,156 )
2005	2005	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	000	6	1/17/2005	COMPETING CONTINUATION	$753,156
														Subtotal = $753,156

Issue Date FY: 2003 ( Subtotal = $620,599 )
2003	2003	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BOULEVARD	WINSTON SALEM	NC	27157	FORSYTH	USA	Cardiovascular Diseases Research	000	5	7/31/2003	NON-COMPETING CONTINUATION	$620,599
														Subtotal = $620,599

Issue Date FY: 2002 ( Subtotal = $613,999 )
2002	2002	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Cardiovascular Diseases Research	000	4	7/3/2002	NON-COMPETING CONTINUATION	$613,999
														Subtotal = $613,999

Issue Date FY: 2001 ( Subtotal = $638,590 )
2001	2001	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Cardiovascular Diseases Research	000	3	7/9/2001	NON-COMPETING CONTINUATION	$638,590
														Subtotal = $638,590

Issue Date FY: 2000 ( Subtotal = $511,073 )
2000	2000	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Cardiovascular Diseases Research	000	2	7/31/2000	NON-COMPETING CONTINUATION	$511,073
														Subtotal = $511,073

Issue Date FY: 1999 ( Subtotal = $527,629 )
1999	1999	WAKE FOREST UNIVERSITY SCHOOL OF MEDICINE	MEDICAL CENTER BOULEVARD	WINSTON-SALEM	NC	27157		USA	Cardiovascular Diseases Research	000	1	8/11/1999	NEW	$527,629
														Subtotal = $527,629

Grand Total All Awards = $6,044,409

Top

All Categories

About

Search

Reports

Data Submission

Award Information

GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS

Award Number: R01HL060944

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/1999

PERIOD OF PERFORMANCE END DATE: 12/31/2010

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer