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Niche Trajectory Analysis of Spatial Omics Data

Award Number: R01HG014190
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/13/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Niche Trajectory Analysis of Spatial Omics Data - PROJECT SUMMARY The maintenance and function of a tissue/organ depends on cell-cell interactions among different cell types. The cell-cell interactome responds and regulates the tissue microenvironment (ME) which is altered in physiological processes such as development and aging, or during the onset and progression of various human diseases. Spatial transcriptomics offers an opportunity to systematically characterize the structural organization of the ME and its changes in various diseases. On the other hand, it requires the development of sophisticated computational methods to achieve these goals. In this project, we will develop a unifying modeling framework, called, ONTraC, and apply it to systematically characterize ME organization in multiple mammalian tissues. A unique feature of the ONTraC framework is that it uses the niche as the basic structural component instead of a cell, as commonly done. The specific aims are: 1. To develop a new framework for constructing niche trajectories from spatial transcriptomic and epigenomic data; 2. To extend the ONTraC framework for analyzing subcellular RNA localization patterns; and 3. To comprehensively characterize the ME organization in acute kidney injury mice through a systems biology approach. Taken together, our proposed research will generate powerful computational tools that will enable biologists and clinicians to investigate the structure and function of ME organization in health and diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,583,834 )
2026	2026	ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI	1 GUSTAVE L LEVY PL	NEW YORK	NY	10029	NEW YORK	USA	Human Genome Research	000	1	4/17/2026	NEW	$2,583,834
														Subtotal = $2,583,834

Grand Total All Awards = $2,583,834

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Niche Trajectory Analysis of Spatial Omics Data

Award Number: R01HG014190

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/13/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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