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Collaborative Research: EDGE FGT: DEVELOPMENT OF FUNCTIONAL GENETIC TOOLS IN GECKOS

Award Number: R01HG013006
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Collaborative Research: EDGE FGT: DEVELOPMENT OF FUNCTIONAL GENETIC TOOLS IN GECKOS - Functional genomic tools, such as CRISPR/cas genome editing, are critical for investigating the biology of genes and have transformed our understanding of genotype-to-phenotype relationships. However, the limited number of species with genome modification methods presents a major bottleneck in implementing comprehensive, comparative studies of gene function. For instance, squamates (lizard and snakes) include more than 11,000 described species and comprise 40% of all amniote species. Yet basic gene editing methods are only available in a single species, the brown anole lizard (Anolis sagrei). Here, we propose to: 1) establish CRISPR/cas gene editing in a second lizard group, the geckos; 2) develop advanced gene editing methods for the introduction of precise sequence substitutions, insertions, and deletions in lizards (in both Anolis and geckos); and 3) disseminate lizard gene editing techniques through training materials and workshops and the production of genome-edited lizards for researchers. The development of gene editing tools in geckos will increase the number of squamate models available for functional genomic work and facilitate the generalization of gene function studies across squamates and amniotes. Furthermore, growing the functional genomic toolkit in lizards to include more precise gene editing methods will expand the scope of questions that can be addressed in this phenotypically diverse group.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $326,213 )
2025	2025	MARQUETTE UNIVERSITY	313 N 13TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Human Genome Research	000	3	12/26/2024	NON-COMPETING CONTINUATION	$293,591
2025	2025	MARQUETTE UNIVERSITY	313 N 13TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Human Genome Research	002	3	5/2/2025	NON-COMPETING CONTINUATION	$0
2025	2025	MARQUETTE UNIVERSITY	313 N 13TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Human Genome Research	001	3	4/28/2025	NON-COMPETING CONTINUATION	$32,622
														Subtotal = $326,213

Issue Date FY: 2024 ( Subtotal = $368,741 )
2024	2024	MARQUETTE UNIVERSITY	313 N 13TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Human Genome Research	001	2	6/13/2024	NON-COMPETING CONTINUATION	$30,101
2024	2024	MARQUETTE UNIVERSITY	313 N 13TH ST	MILWAUKEE	WI	53233	MILWAUKEE	USA	Human Genome Research	000	2	1/10/2024	NON-COMPETING CONTINUATION	$338,640
														Subtotal = $368,741

Issue Date FY: 2023 ( Subtotal = $372,870 )
2023	2023	MARQUETTE UNIVERSITY	915 W WISCONSIN AVE RM 175	MILWAUKEE	WI	53233	MILWAUKEE	USA	Human Genome Research	000	1	2/24/2023	NEW	$372,870
														Subtotal = $372,870

Grand Total All Awards = $1,067,824

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Collaborative Research: EDGE FGT: DEVELOPMENT OF FUNCTIONAL GENETIC TOOLS IN GECKOS

Award Number: R01HG013006

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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