PROJECT SUMMARY / ABSTRACT
High-WhURXghSXW aQd ORZ-cRVW V\QWheViV Rf ORQg DNA fUagPeQWV cRXOd RSeQ XS QeZ fURQWieUV iQ geQRPicV aQd
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Whe SRWeQWiaO WR V\QWheVi]e ORQgeU VeTXeQceV. LibUaUieV Rf RSeQ UeadiQg fUaPeV RU UegXOaWRU\ eOePeQWV haYe
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a chaOOeQge. WideO\-XVed LQ YLWUR DNA aVVePbO\ PeWhRdV, VXch aV GibVRQ aVVePbO\ aQd SRO\PeUaVe chaiQ
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Whe OeQgWh Rf Whe aVVePbOed SURdXcW. IQ addiWiRQ, accXUaWe ORQg aVVePbOieV fURP GH QRYR V\QWheVi]ed DNA aUe
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aVVePbOieV. AW Pa[iPaO WhURXghSXW, Ze eVWiPaWe WhaW RXU WechQRORg\ haV Whe SRWeQWiaO WR SURdXce WhRXVaQdV Rf
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geQe V\QWheViV WechQRORgieV. BecaXVe DNA VWiWchiQg caQ RccXU ZiWhiQ bacWeUiaO aUWificiaO chURPRVRPeV, LQ YLYR
DNA SaUViQg aQd VWiWchiQg caQ SeUfRUP PXOWiSOe[ed aVVePbO\ Rf DNA cRQVWUXcWV e[ceediQg 100kb, aW OeaVW aQ
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VWiWchiQg SURceVV WhaW caQ be bUaQched, aOORZiQg Whe cRQVWUXcWiRQ Rf a Zide YaUieW\ Rf YaUiaQWV aW ORZ
iQcUePeQWaO cRVW. HeUe, Ze SURSRVe WR cRQWiQXe deYeORSPeQW Rf WhiV WechQRORg\ i) b\ bXiOdiQg PaQ\ geQeV WR
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DNA cRQVWUXcWV aQd YaUiaQW OibUaUieV aW ORZ cRVW.