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Telomere-to-telomere assemblies of human genomes

Award Number: R01HG011274
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/14/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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Telomere-to-telomere assemblies of human genomes - PROJECT SUMMARY / ABSTRACT University of California, Santa Cruz Telomere-to-telomere (T2T) assemblies provide complete representations of human genomes, enabling the study of previously unresolved genetic variation relevant to health and disease. However, despite advances in sequencing technologies, generating T2T assemblies remains costly, labor-intensive, and technically complex, limiting their feasibility for large-scale studies. This project aims to develop scalable, cost-effective, and automated workflows for producing fully phased, gap-free genome assemblies with minimal reliance on multiple sequencing platforms and manual intervention. By streamlining the assembly process, these methods will facilitate the generation of large cohorts of high-quality T2T genomes, making complete genomic data more accessible. Additionally, the project will improve the functional annotation of newly resolved genomic regions by integrating long-read sequencing with automated pipelines, enhancing the identification of genes, regulatory elements, and other functional elements.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $773,185 )
2026	2026	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Human Genome Research	000	6	9/3/2026	COMPETING CONTINUATION	$773,185
														Subtotal = $773,185

Issue Date FY: 2024 ( Subtotal = $749,070 )
2024	2024	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Human Genome Research	000	5	7/5/2024	NON-COMPETING CONTINUATION	$734,088
2024	2024	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Human Genome Research	001	5	8/7/2024	NON-COMPETING CONTINUATION	$14,982
														Subtotal = $749,070

Issue Date FY: 2023 ( Subtotal = $749,070 )
2023	2023	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Human Genome Research	000	4	9/19/2023	NON-COMPETING CONTINUATION	$749,070
														Subtotal = $749,070

Issue Date FY: 2022 ( Subtotal = $730,852 )
2022	2022	UNIVERSITY OF CALIFORNIA SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Human Genome Research	001	3	7/25/2022	NON-COMPETING CONTINUATION	$730,852
2022	2021	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Human Genome Research	000	2	12/9/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $730,852

Issue Date FY: 2021 ( Subtotal = $749,146 )
2021	2021	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Human Genome Research	000	2	8/6/2021	NON-COMPETING CONTINUATION	$749,146
														Subtotal = $749,146

Issue Date FY: 2020 ( Subtotal = $736,839 )
2020	2020	UNIVERSITY OF CALIFORNIA, SANTA CRUZ	1156 HIGH ST	SANTA CRUZ	CA	95064	SANTA CRUZ	USA	Human Genome Research	000	1	9/14/2020	NEW	$736,839
														Subtotal = $736,839

Grand Total All Awards = $4,488,162

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Telomere-to-telomere assemblies of human genomes

Award Number: R01HG011274

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/14/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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