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Modeling Functional Elements using CRISPR Screening

Award Number: R01HG010753
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/08/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Modeling Functional Elements using CRISPR Screening - Project Summary The recent development of genome-wide CRISPR/Cas9 screening technology (“CRISPR screens”) identifies functional genes associated with phenotype of interest in a fast and high-throughput manner. Besides protein-coding genes, novel screening techniques enable the functional interrogation of non- coding elements and genetic interactions. We have developed a series of computational algorithms and softwares for the design, quality control, analysis, visualization and interpretation of CRISPR screens. Among these, the MAGeCK/MAGeCK-VISPR algorithms have been widely used for analyzing screening data. In this proposal, we aim to develop the statistical and computational models to improve the functional interrogation of protein-coding genes, and to extend it to study non-coding elements and genetic interactions. Specifically, we propose to: Aim 1. Improve functional gene identification from CRISPR screens, from integrating screening data from heterogenous background and viewing the data in a pathway manner; Aim 2. Develop the design and analysis algorithms for non-coding CRISPR functional studies, and predict functional enhancers across various cell types. Aim 3. Study genetic interactions from CRISPR screens targeting gene pairs, by modeling this novel type of screening data. At the conclusion of these studies, we will have developed several analysis algorithms for CRISPR screens of various types, facilitating the functional studies of genes, non-coding elements and genetic interactions. These algorithms will be made easy and convenient for experimental biologists to answer important biological questions about the functions of protein-coding genes, non-coding elements and genetic interactions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$218,369 )
2026	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Human Genome Research	000	5	12/4/2025	NON-COMPETING CONTINUATION	-$218,369
														Subtotal = -$218,369

Issue Date FY: 2023 ( Subtotal = $715,002 )
2023	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Human Genome Research	001	5	8/30/2023	SUPPLEMENT FOR EXPANSION	$268,752
2023	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Human Genome Research	000	5	6/7/2023	NON-COMPETING CONTINUATION	$446,250
														Subtotal = $715,002

Issue Date FY: 2022 ( Subtotal = $446,250 )
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Human Genome Research	001	4	5/25/2022	NON-COMPETING CONTINUATION	$446,250
2022	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Human Genome Research	000	3	12/3/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $446,250

Issue Date FY: 2021 ( Subtotal = $446,250 )
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Human Genome Research	000	3	5/12/2021	NON-COMPETING CONTINUATION	$446,250
														Subtotal = $446,250

Issue Date FY: 2020 ( Subtotal = $446,250 )
2020	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Human Genome Research	000	2	7/31/2020	NON-COMPETING CONTINUATION	$446,250
														Subtotal = $446,250

Issue Date FY: 2019 ( Subtotal = $446,250 )
2019	2019	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Human Genome Research	000	1	8/8/2019	NEW	$446,250
														Subtotal = $446,250

Grand Total All Awards = $2,281,633

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Modeling Functional Elements using CRISPR Screening

Award Number: R01HG010753

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/08/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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