Thursday, August 21, 2025 8/21/2025

New Computational Tools for Advanced Analytics in Genome-wide Association Studies

Award Number: R01HG009124
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/14/2017
PERIOD OF PERFORMANCE END DATE: 02/28/2027

Group Awards By:

View Award Description

New Computational Tools for Advanced Analytics in Genome-wide Association Studies - Project Summary Many genome-wide association studies (GWAS) have been successfully carried out, identifying numerous genetic variants associated with common diseases and disease related complex traits. The identified genetic associations can now explain a large fraction of the genetic contribution and trait heritability, revealing the genetic architecture underlying common diseases. The success of GWAS in the past few years have laid down a solid foundation both for pursuing the mechanistic insights towards the biology of disease and for transitioning towards new diagnostics and therapeutics in clinical settings. Advancing GWAS towards mechanistic insights and clinical translations, however, urgently requires the development of advanced computational methods that can take advantage of the unique data features and increased data complexity of GWAS as well as the data available from parallel genomics studies. Here, we propose to develop a set of new computational methods to advance GWAS analytics beyond simple variant association analysis and move towards the understanding of the biology of disease and enable potential clinical translations. Specifically, in Aim 1, we will develop integrative methods to integrate GWAS with multiple gene expression mapping studies of distinct genetic ancestries to investigate the molecular mechanisms underlying the variant-trait associations and interrogate the contribution of ancestry specific genetic architecture underlying expression towards gene-trait associations. In Aim 2, we will develop causal inference methods to leverage the genetic associations to improve our understanding of the causal relationship among complex traits and to identify causal risk factors that underlie disease etiology. In Aim 3, we will develop prediction methods to make use of the genetic associations and take advantage of the genetic and environmental correlation among multiple complex traits to facilitate the genetic prediction of disease risk, aiding disease diagnosis and clinical applications. All methods will be implemented in user-friendly open- source software and disseminated to the scientific community. At its conclusion, the proposed study will provide a comprehensive suite of computational methods and software tools for advanced analytics in GWAS. These methods are essential for understanding the transcriptomic and causal mechanism underlying disease etiology, enabling accurate and robust genetic prediction of disease risks, and facilitating biological discoveries and insights.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $312,817 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	000	8	3/7/2025	NON-COMPETING CONTINUATION	$281,536
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	001	8	4/29/2025	NON-COMPETING CONTINUATION	$31,281
														Subtotal = $312,817

Issue Date FY: 2024 ( Subtotal = $312,817 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	003	7	6/12/2024	NON-COMPETING CONTINUATION	$25,536
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	002	7	2/8/2024	NON-COMPETING CONTINUATION	$287,281
2024	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	001	6	1/18/2024	COMPETING CONTINUATION	$600
2024	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	000	5	1/18/2024	NON-COMPETING CONTINUATION	-$600
														Subtotal = $312,817

Issue Date FY: 2023 ( Subtotal = $319,201 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	000	6	4/27/2023	COMPETING CONTINUATION	$319,201
														Subtotal = $319,201

Issue Date FY: 2021 ( Subtotal = $339,696 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	000	5	4/29/2021	NON-COMPETING CONTINUATION	$339,696
														Subtotal = $339,696

Issue Date FY: 2020 ( Subtotal = $340,026 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	000	4	5/5/2020	NON-COMPETING CONTINUATION	$340,026
														Subtotal = $340,026

Issue Date FY: 2019 ( Subtotal = $340,345 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	000	3	4/9/2019	NON-COMPETING CONTINUATION	$340,345
														Subtotal = $340,345

Issue Date FY: 2018 ( Subtotal = $340,311 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	000	2	4/30/2018	NON-COMPETING CONTINUATION	$306,279
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	001	2	6/21/2018	NON-COMPETING CONTINUATION	$34,032
														Subtotal = $340,311

Issue Date FY: 2017 ( Subtotal = $338,886 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Human Genome Research	000	1	6/13/2017	NEW	$338,886
														Subtotal = $338,886

Grand Total All Awards = $2,644,099

Top

All Categories

About

Search

Reports

Data Submission

Award Information

New Computational Tools for Advanced Analytics in Genome-wide Association Studies

Award Number: R01HG009124

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/14/2017

PERIOD OF PERFORMANCE END DATE: 02/28/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer