Friday, December 19, 2025 12/19/2025

Leveraging functional data to predict disease risk in multi-ethnic populations

Award Number: R01HG006399
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/15/2011
PERIOD OF PERFORMANCE END DATE: 05/20/2025

Group Awards By:

View Award Description

Leveraging functional data to predict disease risk in multi-ethnic populations - Genome-wide association studies (GWAS) have been broadly successful in identifying genetic variants associated to common disease risk, leading to successes in predicting disease risk in populations with some genetic ancestries using polygenic risk scores. Unfortunately, there is a large gap in the accuracy of polygenic risk scores in genetically diverse populations, such that clinical efforts to improve biomedical outcomes via precision medicine may have limited success. The increasing availability of data from genetically diverse populations in larger sample sizes provides opportunities to improve the accuracy of polygenic risk scores, by improving localization of causal variants and aiding identification of variants with genetic ancestry-specific effects. Notably, functional genomics data has great potential to improve all of these efforts, but has yet to be adequately included in approaches for analyzing data from genetically diverse populations. Here, we propose to reap the advantages of joint analyses of data from genetically diverse populations and functional data, building on the extensive progress of our research program on disease mapping in genetically diverse populations over the past 8 years; the focus of our current application is on adapting existing statistical methods to a new setting, joint analyses of data from genetically diverse populations and functional data, which currently suffers a large gap in available methods. Our research will be driven by empirical data from >2,500,000 samples from genetically diverse populations (>1,500,000 with genotype/phenotype data and >1,000,000 with summary association statistics) spanning a wide range of diseases and quantitative phenotypes. We will analyze both individual-level data and summary-level data and incorporate functional data sets, including genome-wide functional annotations and gene expression data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Human Genome Research	000	13	11/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Human Genome Research	000	13	5/20/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $441,000 )
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	13	8/14/2024	NON-COMPETING CONTINUATION	$441,000
														Subtotal = $441,000

Issue Date FY: 2023 ( Subtotal = $450,000 )
2023	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	12	8/17/2023	NON-COMPETING CONTINUATION	$450,000
														Subtotal = $450,000

Issue Date FY: 2022 ( Subtotal = $450,000 )
2022	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	002	11	7/1/2022	NON-COMPETING CONTINUATION	$450,000
2022	2021	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	001	10	3/17/2022	COMPETING CONTINUATION	$195,536
2022	2020	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	9	3/17/2022	NON-COMPETING CONTINUATION	-$195,536
														Subtotal = $450,000

Issue Date FY: 2021 ( Subtotal = $476,775 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	002	10	9/27/2021	COMPETING CONTINUATION	$0
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	001	10	9/1/2021	COMPETING CONTINUATION	$476,775
2021	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	9	8/31/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $476,775

Issue Date FY: 2020 ( Subtotal = $475,311 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	9	5/25/2020	NON-COMPETING CONTINUATION	$475,311
														Subtotal = $475,311

Issue Date FY: 2019 ( Subtotal = $475,313 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	8	4/24/2019	NON-COMPETING CONTINUATION	$475,313
														Subtotal = $475,313

Issue Date FY: 2018 ( Subtotal = $475,313 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	001	7	6/29/2018	NON-COMPETING CONTINUATION	$47,534
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	7	5/1/2018	NON-COMPETING CONTINUATION	$427,779
														Subtotal = $475,313

Issue Date FY: 2017 ( Subtotal = $516,826 )
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	002	6	8/25/2017	COMPETING CONTINUATION	$680
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	6	5/3/2017	COMPETING CONTINUATION	$465,143
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	003	6	9/11/2017	COMPETING CONTINUATION	$51,683
2017	2015	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	001	5	8/25/2017	NON-COMPETING CONTINUATION	-$680
														Subtotal = $516,826

Issue Date FY: 2015 ( Subtotal = $502,123 )
2015	2015	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	5	4/28/2015	NON-COMPETING CONTINUATION	$502,123
														Subtotal = $502,123

Issue Date FY: 2014 ( Subtotal = $504,700 )
2014	2014	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	4	4/25/2014	NON-COMPETING CONTINUATION	$504,700
														Subtotal = $504,700

Issue Date FY: 2013 ( Subtotal = $491,824 )
2013	2013	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	3	5/15/2013	NON-COMPETING CONTINUATION	$491,824
														Subtotal = $491,824

Issue Date FY: 2012 ( Subtotal = $515,000 )
2012	2012	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	2	4/30/2012	NON-COMPETING CONTINUATION	$515,000
														Subtotal = $515,000

Issue Date FY: 2011 ( Subtotal = $515,000 )
2011	2011	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Human Genome Research	000	1	6/14/2011	NEW	$515,000
														Subtotal = $515,000

Grand Total All Awards = $6,289,185

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Leveraging functional data to predict disease risk in multi-ethnic populations

Award Number: R01HG006399

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/15/2011

PERIOD OF PERFORMANCE END DATE: 05/20/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer