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High Resolution Mapping of Functional Elements in the Yeast Genome

Award Number: R01HG004160
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/11/2020
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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High Resolution Mapping of Functional Elements in the Yeast Genome - The budding yeast Saccharomyces cerevisiae is used as model system to understand genomic mechanisms by which chromatin organization is established. The start sites of genes, or promoters, are typically encased in a nucleosome-free region, that is bookended with two well-positioned nucleosomes. This precise organization is standard for most genes, and plays into how these genes are regulated. Therefore a fundamental understanding of gene regulatory mechanisms requires a complete understanding of how such canonical nucleosome organization arises and guides the placement of the transcription machinery. The proposed work will take advantage of biochemical reconstitution of aspects of canonical nucleosome organization on a genomic scale. This will allow individual mechanistic contributions of chromatin organizing factors and their effectors to be explicitly defined. In particular, how ATP-dependent chromatin remodeler complexes recognize DNA features and sequence-specific organizing factors, will be addressed. The organization of chromatin directs the organized assembly of the transcription machinery. Biochemical reconstitution will be used to tease apart selected individual contributions of chromatin organization and activator/repressor binding towards assembly of the transcription machinery on a genomic scale. Chromatin is generally thought to be composed of nucleosome particles containing 2 copies of each of the four core histones. However, it is now becoming clear that various partially assembled nucleosomes or subnucleosomes exist in vivo, and these structures may play critical roles in chromatin dynamics. The existence of these substructures and the histone chaperones that are likely to be involved in their assembly and disassembly will be investigated on a genomic scale.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$6,911 )
2024	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Human Genome Research	000	16	7/3/2024	NON-COMPETING CONTINUATION	-$6,911
														Subtotal = -$6,911

Issue Date FY: 2022 ( Subtotal = $400,721 )
2022	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Human Genome Research	000	16	2/15/2022	NON-COMPETING CONTINUATION	$360,648
2022	2022	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Human Genome Research	001	16	4/27/2022	NON-COMPETING CONTINUATION	$40,073
														Subtotal = $400,721

Issue Date FY: 2021 ( Subtotal = $401,002 )
2021	2021	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Human Genome Research	002	15	2/22/2021	NON-COMPETING CONTINUATION	$401,002
2021	2020	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Human Genome Research	001	14	2/5/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$6,911
2021	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	13	2/5/2021	NON-COMPETING CONTINUATION	-$6,911
														Subtotal = $401,002

Issue Date FY: 2020 ( Subtotal = $385,526 )
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	13	2/20/2020	NON-COMPETING CONTINUATION	$385,526
2020	2020	CORNELL UNIVERSITY	341 PINE TREE RD	ITHACA	NY	14850	TOMPKINS	USA	Human Genome Research	002	14	9/9/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$220,550
2020	2020	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	001	13	9/9/2020	NON-COMPETING CONTINUATION	-$220,550
														Subtotal = $385,526

Issue Date FY: 2019 ( Subtotal = $392,781 )
2019	2019	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	001	12	2/6/2019	NON-COMPETING CONTINUATION	$385,741
2019	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	11	11/29/2018	COMPETING CONTINUATION	$1,245
2019	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	002	11	5/8/2019	COMPETING CONTINUATION	$5,795
														Subtotal = $392,781

Issue Date FY: 2018 ( Subtotal = $322,724 )
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	002	11	9/25/2018	COMPETING CONTINUATION	$36,961
2018	2018	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	001	11	4/27/2018	COMPETING CONTINUATION	$285,763
2018	2016	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	10	3/7/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $322,724

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	001	10	8/30/2017	EXTENSION WITH OR WITHOUT FUNDS	$0
2017	2015	PENNSYLVANIA STATE UNIVERSITY, THE	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	9	12/7/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $369,691 )
2016	2016	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	10	6/16/2016	EXTENSION WITH OR WITHOUT FUNDS	$369,691
														Subtotal = $369,691

Issue Date FY: 2015 ( Subtotal = $360,554 )
2015	2015	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	9	6/24/2015	NON-COMPETING CONTINUATION	$360,554
														Subtotal = $360,554

Issue Date FY: 2014 ( Subtotal = $362,505 )
2014	2014	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	8	5/28/2014	NON-COMPETING CONTINUATION	$362,505
														Subtotal = $362,505

Issue Date FY: 2013 ( Subtotal = $370,003 )
2013	2013	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	7	7/30/2013	COMPETING CONTINUATION	$370,003
														Subtotal = $370,003

Issue Date FY: 2012 ( Subtotal = $346,500 )
2012	2012	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	6	6/8/2012	NON-COMPETING CONTINUATION	$346,500
														Subtotal = $346,500

Issue Date FY: 2011 ( Subtotal = $346,500 )
2011	2011	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	5	6/30/2011	NON-COMPETING CONTINUATION	$346,500
														Subtotal = $346,500

Issue Date FY: 2010 ( Subtotal = $350,000 )
2010	2010	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	4	9/13/2010	COMPETING CONTINUATION	$350,000
														Subtotal = $350,000

Issue Date FY: 2009 ( Subtotal = $308,378 )
2009	2009	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	3	6/22/2009	NON-COMPETING CONTINUATION	$308,378
														Subtotal = $308,378

Issue Date FY: 2008 ( Subtotal = $308,345 )
2008	2008	PENNSYLVANIA STATE UNIVERSITY	110 TECHNOLOGY CENTER BUILDING	UNIVERSITY PARK	PA	16802	CENTRE	USA	Human Genome Research	000	2	6/20/2008	NON-COMPETING CONTINUATION	$308,345
														Subtotal = $308,345

Issue Date FY: 2007 ( Subtotal = $324,359 )
2007	2007	PENNSYLVANIA STATE UNIVERSITY	313 RIDER BUILDING	UNIVERSITY PARK	PA	16801		USA	Human Genome Research	000	1	7/26/2007	NEW	$324,359
														Subtotal = $324,359

Grand Total All Awards = $5,342,679

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High Resolution Mapping of Functional Elements in the Yeast Genome

Award Number: R01HG004160

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/11/2020

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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