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HIGH-SPEED NANOPORE GENE SEQUENCING

Award Number: R01HG003565
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 09/29/2004
PERIOD OF PERFORMANCE END DATE: 09/30/2007

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HIGH-SPEED NANOPORE GENE SEQUENCING - DESCRIPTION (provided by applicant): Significant enhancements in gene sequencing may be achieved through implementation of analysis instruments at the same dimensional scale as DNA, i.e nanometers. Nanotechnology has recently provided the necessary tools to create such nanoinstruments and this proposal seeks to utilize these tools to fabricate a high-speed, low-cost gene sequencer. The gene sequencer is based on the nanopore approach and incorporates tunneling current electrodes to sense the individual nucleotides as they transverse the pore. Specific aims for this proposal are: 1). Design and fabricate nanopore devices complete with tunneling current electrodes and integrated sense and control circuitry on a chip. 2). Characterize the nanopore device using known ssDNA sequences. Initial characterization will be limited to DNA strands of approximately 1000 bases. Subsequent evaluations will include selected bacteria, and mammalian (mouse) DNA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $177,520 )
2006	2006	UNIVERSITY OF MAINE, PORTLAND-GORHAM	96 FALMOUTH STREET	PORTLAND	ME	04103	CUMBERLAND	USA	Human Genome Research	000	3	5/5/2006	NON-COMPETING CONTINUATION	$177,520
														Subtotal = $177,520

Issue Date FY: 2005 ( Subtotal = $359,195 )
2005	2005	UNIVERSITY OF MAINE, PORTLAND-GORHAM	96 FALMOUTH STREET	PORTLAND	ME	04103	CUMBERLAND	USA	Human Genome Research	000	2	6/22/2005	NON-COMPETING CONTINUATION	$359,195
														Subtotal = $359,195

Issue Date FY: 2004 ( Subtotal = $314,060 )
2004	2004	UNIVERSITY OF MAINE, PORTLAND-GORHAM	96 FALMOUTH STREET	PORTLAND	ME	04103	CUMBERLAND	USA	Human Genome Research	000	1	9/27/2004	NEW	$314,060
														Subtotal = $314,060

Grand Total All Awards = $850,775

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HIGH-SPEED NANOPORE GENE SEQUENCING

Award Number: R01HG003565

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 09/29/2004

PERIOD OF PERFORMANCE END DATE: 09/30/2007

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