Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

PhysicaL Activity recoverY (PLAY) after critical lung injury in children

Award Number: R01HD118996
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/04/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2031

Group Awards By:

View Award Description

PhysicaL Activity recoverY (PLAY) after critical lung injury in children - ABSTRACT Every year, more than 40,000 children in the United States require admission to a Pediatric Intensive Care Unit (PICU) for support with invasive mechanical ventilation. Due to their severe illness, invasive ventilation support, and associated PICU-exposures, these patients are at high risk of developing physical health impairments that persist beyond the acute illness period. Physical health impairments restrict a child's ability to play, attend school, and socialize, leading to profound negative impacts on their social, cognitive, and emotional development. Physical activity is a key component of physical health and a driver of long-term health outcomes. Physical activity can be objectively and remotely measured and tracked using activity monitors. Our group has demonstrated the ability to objectively measure physical activity using activity monitors after hospital discharge in pediatric survivors of critical illness. In this proposal, we will directly measure physical activity in children who survive acute respiratory disease requiring invasive mechanical ventilation across a multicenter cohort. We will prospectively enroll 260 previously ambulatory critically ill children (5 to 18 years) who are invasively ventilated for 48 hours or longer for acute respiratory disease. We will measure physical activity for 14 days using activity monitors at two time points: immediately after hospital discharge and 3-months post- discharge. We will test the hypothesis that patient clusters identified by physical activity amount and intensity will correspond to meaningful patient-centered outcomes such that clusters with higher physical activity will exhibit higher 3-month health-related quality of life (Aim 1a). In a subset of this cohort (n=50), we will conduct qualitative interviews to develop a comprehensive understanding of the barriers and facilitators to physical activity after PICU discharge (Aim 1b). In a separate cohort of children (n=50) with identical enrollment criteria as aim 1a, we will conduct a two-center open label randomized controlled pilot study to determine whether a post-discharge rehabilitation program informed by activity monitoring will increase physical activity (Aim 2). The 3-month rehabilitation program will be delivered remotely via telehealth by a Physical Therapist with support from a Child Life Specialist. It will be personalized based on remote assessments and physical activity data collected using activity monitors. We anticipate the results from this proposal will pave the way for use of physical activity as an innovative, objective outcome for future PICU trials. Additionally, it will provide the information necessary to design and execute a trial to increase physical activity in children who survive critical illness, ultimately contributing to improved long-term physical, cognitive, social, and emotional outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $636,728 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	1	8/6/2026	NEW	$636,728
														Subtotal = $636,728

Grand Total All Awards = $636,728

Top

All Categories

About

Search

Reports

Data Submission

Award Information

PhysicaL Activity recoverY (PLAY) after critical lung injury in children

Award Number: R01HD118996

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/04/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2031

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer