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Modeling and Characterizing the Genomic Consequences of MED12 Mutations in Uterine Fibroids

Award Number: R01HD117479
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Modeling and Characterizing the Genomic Consequences of MED12 Mutations in Uterine Fibroids - ABSTRACT Uterine fibroids (leiomyomas) are the most widely observed tumors in women. By age 50, more than ~70% of white and more than 80% of black women develop at least one UF tumor. Although non-malignant, they disrupt normal uterine function and cause severe health problems ~25% of reproductive-age women. The most common subtype, representing ~70% of all fibroids, is caused by recurrent somatic mutations in the MED12 gene that encodes the mediator of transcription subunit 12 (MED12) protein. The lack of proper model systems hampered our mechanistic understanding of UF development and identifying effective treatment strategies. Our long-term goal is to interrogate the functional role of driver genetic mutations in fibroid tumors and identify potential targetable mechanisms downstream of these mutations. Our objective in this proposal, a critical step toward our long-term goal, is to create and exploit disease-relevant human cellular models of UF by CRISPR engineering specific MED12 mutations, decipher their functional role in driving UF tumorigenesis and identify druggable mechanisms to target mutant cells selectively.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $678,013 )
2026	2026	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Child Health and Human Development Extramural Research	000	2	5/19/2026	NON-COMPETING CONTINUATION	$678,013
														Subtotal = $678,013

Issue Date FY: 2025 ( Subtotal = $688,000 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Child Health and Human Development Extramural Research	000	1	8/4/2025	NEW	$688,000
														Subtotal = $688,000

Grand Total All Awards = $1,366,013

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Modeling and Characterizing the Genomic Consequences of MED12 Mutations in Uterine Fibroids

Award Number: R01HD117479

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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