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Using 2D and 3D adrenal gland tissues to investigate developmental and disease paradigms

Award Number: R01HD115812
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/06/2025
PERIOD OF PERFORMANCE END DATE: 04/30/2030

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Using 2D and 3D adrenal gland tissues to investigate developmental and disease paradigms - Project summary/Abstract The adrenal glands are vital endocrine organs, comprising the medulla and cortex, that control stress responses, metabolism, blood pressure, and immunity. We hypothesize that better understanding of medulla and cortex development, their interaction and pathologies will unlock novel treatment options for adrenal gland disorders. Our long-term goal is to use human pluripotent stem cell (hPSC)-derived 2D and 3D models to explore adrenal gland development, disorders, and therapies. Using hPSCs, we have made progress in generating adrenal gland cell types in 2D and 3D, laying the foundation for the proposed studies. Medullary chromaffin cells originate from neural crest (NC, ~20%) and Schwann cell progenitors (SCPs, ~80%), but the reason for this dual origin remains unknown. We will differentiate NC- and SCP-derived chromaffin cells in 2D and 3D and assess differences in their functions and physiological responsibilities. Adrenal gland insufficiencies are treated with hormone- replacement therapies targeting the cortex only. There is evidence that the influence of the medulla is substantial in homeostasis and disease, but it remains unknown if and which paracrine signals mediate this communication. We will use co-culture systems to identify molecules that mediate this interaction and will explore the role of defective communication in Congenital Adrenal Hyperplasia (CAH) 3D organoids. Current standard of care hormone-replacement therapy falls short of addressing daily, dynamic and demand-based patient’s needs. We generate 3D adrenal gland organoids for a cell replacement therapy approach for adrenal insufficiency. Our research efforts will advance our understanding of adrenal gland development, the significance of its multiple developmental origins, and medulla-cortex communication's role in health. Additionally, we'll gain insights into potential cell therapy approaches for adrenal gland diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $646,707 )
2026	2026	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Child Health and Human Development Extramural Research	000	2	5/18/2026	NON-COMPETING CONTINUATION	$646,707
														Subtotal = $646,707

Issue Date FY: 2025 ( Subtotal = $718,499 )
2025	2025	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Child Health and Human Development Extramural Research	000	1	5/7/2025	NEW	$718,499
														Subtotal = $718,499

Grand Total All Awards = $1,365,206

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Using 2D and 3D adrenal gland tissues to investigate developmental and disease paradigms

Award Number: R01HD115812

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/06/2025

PERIOD OF PERFORMANCE END DATE: 04/30/2030

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