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Personalized Hip vs Ankle Exoskeleton Assistance with Biofeedback to Enhance Mobility Post-Stroke

Award Number: R01HD113598
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Personalized Hip vs Ankle Exoskeleton Assistance with Biofeedback to Enhance Mobility Post-Stroke - Project Abstract Stroke survivors experience profound mobility challenges limiting community ambulation which impacts overall quality of life. Studies show mobility is strongly linked to quality of life, participation, and well-being, and robotic exoskeleton assistive devices have significant potential to improve mobility by providing assistance at lower limb joints. However, no technology enabling personalization to individuals with varying mobility needs exists. This proposal aims to understand how optimized ankle and hip exoskeletons in combination with biofeedback can impact mobility post-stroke. The overarching hypothesis is that targeted biofeedback combined with optimized exoskeleton assistance can improve community ambulation capability across a cohort of stroke survivors with variable baseline gait function. In order to optimize exoskeleton assistance for individuals post-stroke, the team will address 3 aims. Aim 1 will determine and compare the benefit of personalized hip and ankle exoskeleton assistance for bilateral improvement of post-stroke gait. To compensate for distal ankle weakness, stroke survivors often compensate with the hip joint. Therefore, the hypothesis is that assistance targeted at the hip may provide a larger improvement in walking speed. Aim 2 will combine exoskeleton technology with biofeedback to enhance and synchronize wearable robotic assistance to an individual stroke survivor’s gait pattern. The hypothesis is that biofeedback to improve paretic leg positioning will work synergistically with both hip and ankle exoskeletons to improve stroke gait mechanics and walking speed. Further, it is expected that larger improvements will be observed with the ankle exoskeleton assistance combined with biofeedback because improved paretic leg positioning will enable greater forward propulsion of the CoM during ankle exoskeleton use. Aim 3 will evaluate and compare clinically relevant outcomes with and without the optimized technologies in real- world environments in an effort toward clinical translation. This work leverages a novel self-adaptive AI system to optimize performance of post-stroke gait coupled with biofeedback in clinically-applicable exoskeletons. This work will fundamentally innovate new technology in 3 key areas: 1) New AI and optimization systems to personalize exoskeleton control to post-stroke gait, 2) A new wearable overground biofeedback system to cue exoskeleton users to improve gait mechanics, and 3) Implementation of these systems on state- of-the-art exoskeletons with clinical testing in stroke survivors and applications to community ambulation. Concurrently, the work has scientific impact through the analysis of the biomechanics of hip compensation for ankle weakness and the associated hip-ankle trade-off changes that occur with ankle and hip exoskeletons and targeted biofeedback. Lastly, this work aims to push for clinical translation through targeted comparisons of clinical outcomes in stroke survivors ambulating in real world settings with and without the new technologies. Ultimately, the project outcomes will enable personalized assistive devices to improve post-stroke community mobility and overall quality of life.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $461,879 )
2026	2026	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Child Health and Human Development Extramural Research	000	3	1/19/2026	NON-COMPETING CONTINUATION	$461,879
														Subtotal = $461,879

Issue Date FY: 2025 ( Subtotal = $514,714 )
2025	2025	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Child Health and Human Development Extramural Research	001	2	4/22/2025	NON-COMPETING CONTINUATION	$51,472
2025	2025	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Child Health and Human Development Extramural Research	000	2	1/23/2025	NON-COMPETING CONTINUATION	$463,242
														Subtotal = $514,714

Issue Date FY: 2024 ( Subtotal = $562,054 )
2024	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Child Health and Human Development Extramural Research	001	1	4/15/2024	NEW	$0
2024	2024	GEORGIA TECH RESEARCH CORP	926 DALNEY ST NW	ATLANTA	GA	30318	FULTON	USA	Child Health and Human Development Extramural Research	000	1	3/28/2024	NEW	$562,054
														Subtotal = $562,054

Grand Total All Awards = $1,538,647

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Personalized Hip vs Ankle Exoskeleton Assistance with Biofeedback to Enhance Mobility Post-Stroke

Award Number: R01HD113598

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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