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Role of PFC Activity in the Behavioral Deficits Induced by Maternal Separation

Award Number: R01HD110541
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/11/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Role of PFC Activity in the Behavioral Deficits Induced by Maternal Separation - Project Summary Environmental factors have profound influence on brain plasticity during early-life. Maternal care arguably has the greatest influence on this process, with neglect resulting in an array of mental health issues in adolescents and adults. Childhood adversity (physical abuse, neglect, food insecurity, violence) is estimated to account for up to 45% of child-onset and 32% of adult-onset mental health disorders. Neglect is the most prevalent form of childhood maltreatment in the United States. Neural activity in early life shapes circuit development and can have lifelong consequences on brain function. The prefrontal cortex (PFC) is late-developing, making it more susceptible to early-life adversity. Our previous study revealed that maternal presence/absence from the nest regulates the activity of the PFC of rat pups at postnatal day 11 via the serotonergic system. In this study, we propose to test the relation between PFC activity during early-life and behavioral expression in adulthood. In Aim 1, using single nucleus RNA sequencing, we will test how early-life adversity affects the expression profile of distinct cell populations. Furthermore, using voltage dye imaging, we will test how early-life adversity affects PFC activity in the immediate and long-term. In Aim 2, we will test whether activation or inhibition of the PFC in early- life is causal or protective of long-term behavioral deficits associated with maternal separation. In Aim 3, we will test whether a decrease in serotonergic activity during early-life is sufficient to produce the behavioral deficits observed after maternal separation and, ultimately, whether normalizing serotonin levels in the PFC during maternal separation can prevent the development of behavioral deficits.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $464,413 )
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	4	3/3/2026	NON-COMPETING CONTINUATION	$464,413
														Subtotal = $464,413

Issue Date FY: 2025 ( Subtotal = $464,413 )
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	3	2/20/2025	NON-COMPETING CONTINUATION	$417,972
2025	2025	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	001	3	5/13/2025	NON-COMPETING CONTINUATION	$46,441
														Subtotal = $464,413

Issue Date FY: 2024 ( Subtotal = $468,066 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	001	2	6/10/2024	NON-COMPETING CONTINUATION	$42,551
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	2	2/22/2024	NON-COMPETING CONTINUATION	$425,515
														Subtotal = $468,066

Issue Date FY: 2023 ( Subtotal = $485,794 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Child Health and Human Development Extramural Research	000	1	4/11/2023	NEW	$485,794
														Subtotal = $485,794

Grand Total All Awards = $1,882,686

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Role of PFC Activity in the Behavioral Deficits Induced by Maternal Separation

Award Number: R01HD110541

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/11/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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