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The Multi-Omic Milk (MuMi) Study: Leveraging the IMiC Platform and the CHILD Cohort to study human milk as a biological system and understand its composition, determinants and impacts on child health

Award Number: R01HD109859
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/12/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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The Multi-Omic Milk (MuMi) Study: Leveraging the IMiC Platform and the CHILD Cohort to study human milk as a biological system and understand its composition, determinants and impacts on child health - PROJECT SUMMARY Significance: Human milk (HM) has evolved over millions of years to nourish and protect human infants - yet we know surprisingly little about its composition, variation, and function. Traditionally, HM research has focused on individual HM components, yet HM is a complex biological system comprising thousands of components that interact and function in combination. Moreover, while HM composition is known to be affected by maternal, infant, and environmental factors, these are poorly understood and rarely examined simultaneously. To address these gaps, our team is championing a multi-omics systems biology approach to study HM as a “system within a system”, reflecting that milk itself is a system embedded within the “mother-milk-infant” triad. Approach: This grant will leverage and unite two established HM research platforms to investigate HM and its determinants and health impacts among 1600 mother-infant dyads using a novel multi-omic approach. The International Milk Composition (IMiC) Consortium is a network of HM researchers and data scientists with an established infrastructure for multi-omic HM research. CHILD is an ongoing national pregnancy cohort of 3600 children born in 2009-12. Our team has already analyzed 1600 CHILD HM samples for 19 oligosaccharides, 28 fatty acids, and hundreds of bacteria. We will now enhance the rich CHILD dataset with new multi-omic HM analyses (20 nutrients, 15 non-nutritive bioactive proteins and thousands of metabolites) and apply unsupervised machine learning methods to identify discrete ‘lactotypes’ (Aim 1). Next, we will leverage the rich CHILD data to identify maternal, infant and environmental factors associated with lactotype membership and/or individual HM components (Aim 2). Finally, we will use machine learning methods to understand how HM composition influences microbiome development, growth, wheezing and allergies during infancy and childhood (Aim 3). Innovation: Integrating the CHILD and IMiC platforms will facilitate unprecedented research on HM as a system-within-a-system and generate the world’s largest and most deeply-phenotyped mother-milk-infant dataset (n=1600 triads with multi-omic milk profiles and rich longitudinal maternal and infant metadata). This project will unite expert HM scientists, renowned pediatric researchers and data scientists at the forefront of multi-omic methods development, placing the interdisciplinary MuMi team in an unrivaled position to make novel discoveries in this space and revolutionize the way HM is studied and understood.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $545,085 )
2025	2025	THE UNIVERSITY OF MANITOBA	402 ADMINISTRATION BUILDING	WINNIPEG	MB			CAN	Child Health and Human Development Extramural Research	000	4	8/4/2025	NON-COMPETING CONTINUATION	$545,085
														Subtotal = $545,085

Issue Date FY: 2024 ( Subtotal = $702,998 )
2024	2024	THE UNIVERSITY OF MANITOBA	402 ADMINISTRATION BUILDING	WINNIPEG	MB			CAN	Child Health and Human Development Extramural Research	001	3	7/16/2024	NON-COMPETING CONTINUATION	$502,998
2024	2023	THE UNIVERSITY OF MANITOBA	402 ADMINISTRATION BUILDING	WINNIPEG	MB			CAN	Child Health and Human Development Extramural Research	000	2	6/19/2024	NON-COMPETING CONTINUATION	$200,000
														Subtotal = $702,998

Issue Date FY: 2023 ( Subtotal = $492,078 )
2023	2023	UNIVERSITY OF MANITOBA THE	311 ADMINISTRATION BLDG	WINNIPEG	MB			CAN	Child Health and Human Development Extramural Research	001	2	7/12/2023	NON-COMPETING CONTINUATION	$492,078
2023	2022	UNIVERSITY OF MANITOBA THE	311 ADMINISTRATION BLDG	WINNIPEG	MB			CAN	Child Health and Human Development Extramural Research	000	1	5/11/2023	NEW	$0
														Subtotal = $492,078

Issue Date FY: 2022 ( Subtotal = $401,241 )
2022	2022	UNIVERSITY OF MANITOBA THE	311 ADMINISTRATION BLDG	WINNIPEG	MB			CAN	Child Health and Human Development Extramural Research	000	1	8/4/2022	NEW	$401,241
														Subtotal = $401,241

Grand Total All Awards = $2,141,402

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The Multi-Omic Milk (MuMi) Study: Leveraging the IMiC Platform and the CHILD Cohort to study human milk as a biological system and understand its composition, determinants and impacts on child health

Award Number: R01HD109859

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/12/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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