Thursday, September 18, 2025 9/18/2025

Dynamic Imaging of Cerebral Palsy Gait

Award Number: R01HD108205
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Dynamic Imaging of Cerebral Palsy Gait - PROJECT SUMMARY/ABSTRACT Cerebral palsy (CP) results from a perinatal brain injury and is one of the most prevalent and costly pediatric neurologic conditions in the United States. Individuals with CP frequently experience lifelong mobility challenges. The modern treatment approaches being used to overcome these challenges place greater emphasis on the neurological basis for how youth with CP plan their leg movements, execute motor actions, and integrate sensory information. Despite this neuroscience-informed approach, these new therapies are still limited by substantial knowledge gaps regarding how the aberrant sensorimotor cortical activity and/or spinal cord specifically affects the gait of youth with CP. Our ultramodern magnetoencephalographic (MEG) brain imaging results have revealed that cortical aberrations play a substantial role in the uncharacteristic leg motor actions and sensory processes seen in youth with CP. Furthermore, our high-resolution MRI pipelines have shown that the structural integrity of spinal cord tissue is compromised in individuals with CP. From these experiments, we have inferred that the altered cortical dynamics and spinal cord integrity likely impacts the ability of youth with CP to make feed-forward predictions and/or online corrections to their leg kinematics during gait. However, this conjecture has yet to be fully established due to physical limitations of the MEG/MRI recording environments. To move forward, we will use our extensive MEG foundational work to develop new electroencephalographic (EEG) methods that have the scientific rigor and flexibility to precisely quantify the sensorimotor cortical activity during real-time gait. Furthermore, we will utilize cutting-edge neurophysiological tests to concurrently quantify how the spinal cord interneuronal dynamics are modulated during gait. The Aims of this study will: (1) establish multimodal MEG-EEG neuroimaging proxies of the aberrant sensorimotor cortical oscillations seen in youth with CP that are known to impact the extent of the mobility deficits, (2) quantify the sensorimotor EEG cortical oscillations and spinal cord interneuronal dynamics of youth with CP during gait, and (3) decipher if alterations in the sensorimotor cortical oscillations and spinal cord interneuronal dynamics are better predictors of the mobility deficits seen in youth with CP relative to the most commonly used clinical metrics. To achieve these Aims, youth with CP and neurotypical controls will undergo a series of experiments that will use simultaneous MEG-EEG neuroimaging, EEG neuroimaging during gait, and assessments of the spinal cord interneuronal dynamics during gait. Furthermore, the participants will undergo a battery of clinical assessments (e.g., balance, spasticity, selective control, strength and sensation). We foresee that the body of new knowledge gained through this project will set-the-stage for the design and testing of innovative therapeutic protocols that target the specific neurophysiological deficits that are limiting the mobility of youth with CP.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $675,864 )
2025	2025	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Child Health and Human Development Extramural Research	001	4	7/21/2025	NON-COMPETING CONTINUATION	$675,864
2025	2024	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	3	5/22/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $675,864

Issue Date FY: 2024 ( Subtotal = $609,651 )
2024	2024	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	3	8/12/2024	NON-COMPETING CONTINUATION	$609,651
														Subtotal = $609,651

Issue Date FY: 2023 ( Subtotal = $650,647 )
2023	2023	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	2	8/17/2023	NON-COMPETING CONTINUATION	$650,647
														Subtotal = $650,647

Issue Date FY: 2022 ( Subtotal = $616,374 )
2022	2022	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	1	9/19/2022	NEW	$616,374
														Subtotal = $616,374

Grand Total All Awards = $2,552,536

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Dynamic Imaging of Cerebral Palsy Gait

Award Number: R01HD108205

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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