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Impact of Maternal Inflammation and Cell Trafficking on Fetal Immune Ontogeny

Award Number: R01HD107737
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/06/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2029

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Impact of Maternal Inflammation and Cell Trafficking on Fetal Immune Ontogeny - PROJECT SUMMARY / ABSTRACT These investigations explore the hypothesis that maternal inflammation due to acute or chronic virus infection during pregnancy has a durable impact on the development of the fetal immune system, which is mediated by changes in placental function and transplacental transfer of metabolites and inflammatory mediators to the fetus. Our studies have shown that subclinical rhesus cytomegalovirus (RhCMV) infection during pregnancy is associated with dramatic alterations of immune function in offspring—demonstrating a vertical effect of maternal inflammation on immune system development. Our prior studies have also demonstrated a fetal response that impacts how microglial cells, the resident immune cells of the central nervous system, engage and engulf neural precursor cells. These investigations will probe the link between maternal, placental, and fetal inflammation in a translational primate model system that closely recapitulates human development and disease, and using state-of-the-art tools and technologies through the following Specific Aims: (1) Determine the impact of acute maternal RhCMV infection and consequent inflammation on fetal innate and adaptive immune functions, in seronegative and seropositive dams; (2) Assess the impact of acute and chronic RhCMV infection on the placenta and maternal-fetal cell trafficking; and (3) Test the postnatal consequences of fetal immune development in the context of maternal infection with RhCMV and associated inflammation. The studies proposed are designed to test the hypothesis that maternal, placental, and fetal immune responses contribute to developmental sequelae including alterations in postnatal immunity, providing key insights on a common worldwide maternal and congenital infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $678,065 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	2	2/13/2025	NON-COMPETING CONTINUATION	$610,259
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	001	2	4/14/2025	NON-COMPETING CONTINUATION	$67,806
														Subtotal = $678,065

Issue Date FY: 2024 ( Subtotal = $678,065 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	1	5/6/2024	NEW	$678,065
														Subtotal = $678,065

Grand Total All Awards = $1,356,130

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Impact of Maternal Inflammation and Cell Trafficking on Fetal Immune Ontogeny

Award Number: R01HD107737

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/06/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2029

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