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Regulation of adrenal development and function by the mother's skeleton

Award Number: R01HD107574
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/23/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Regulation of adrenal development and function by the mother's skeleton - PROJECT SUMMARY The overall goal of this Application is to improve our understanding of the genetic and molecular control of adrenal gland homeostasis by studying how osteocalcin originating from maternal skeleton, affects adrenal growth and steroidogenesis of the offspring during development and after birth. Specifically we intend to 1] Establish that maternal Ocn is necessary for proper adrenal gland development and function. We will also 2] Establish genetically and in vivo that osteocalcin favors adrenal gland growth and steroidogenesis by signalling directly in the adrenal cortices through its receptor Gpr158. A third purpose of this application is to determine with precision the temporal course of osteocalcin’s effect on the adrenal gland development/function and investigate how maternal osteocalcin affects this process in the offspring. We will use mouse genetic, molecular and biochemical assays to investigate the molecular bases of the cross-talk between bone and the adrenal gland through osteocalcin in the regulation of adrenal steroid production. Together, this application will significantly advance our understanding of adrenal development and physiology in bony vertebrates by describing a novel regulation of adrenal gland development and steroidogenesis, which originates from the mother and is biologically relevant since its absence can be lethal.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $326,908 )
2025	2025	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	005	6	7/5/2025	NON-COMPETING CONTINUATION	$337,550
2025	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	001	5	3/20/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$334,175
2025	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	002	5	3/21/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2024	RUTGERS THE STATE UNIVERSITY OF NEW JERSEY	65 BERGEN ST	NEWARK	NJ	07107	ESSEX	USA	Child Health and Human Development Extramural Research	004	5	4/10/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$84,940
2025	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Child Health and Human Development Extramural Research	000	4	3/20/2025	NON-COMPETING CONTINUATION	-$344,817
2025	2023	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Child Health and Human Development Extramural Research	003	3	4/10/2025	NON-COMPETING CONTINUATION	-$84,940
														Subtotal = $326,908

Issue Date FY: 2024 ( Subtotal = $344,817 )
2024	2024	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Child Health and Human Development Extramural Research	000	4	7/17/2024	NON-COMPETING CONTINUATION	$344,817
														Subtotal = $344,817

Issue Date FY: 2023 ( Subtotal = $348,300 )
2023	2023	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Child Health and Human Development Extramural Research	000	3	7/11/2023	NON-COMPETING CONTINUATION	$348,300
														Subtotal = $348,300

Issue Date FY: 2022 ( Subtotal = $348,300 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Child Health and Human Development Extramural Research	000	2	7/25/2022	NON-COMPETING CONTINUATION	$348,300
														Subtotal = $348,300

Issue Date FY: 2021 ( Subtotal = $348,300 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Child Health and Human Development Extramural Research	000	1	9/23/2021	NEW	$348,300
														Subtotal = $348,300

Grand Total All Awards = $1,716,625

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Regulation of adrenal development and function by the mother's skeleton

Award Number: R01HD107574

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/23/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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