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Novel Pediatric Sepsis Criteria and Clinical Decision Support Tools

Award Number: R01HD105939
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Novel Pediatric Sepsis Criteria and Clinical Decision Support Tools - PROJECT SUMMARY/ABSTRACT Pediatric sepsis is a major global public health problem associated with millions of deaths every year. In the United States, 1 in every 10-15 children with sepsis or septic shock will die during their hospitalization, and many survivors will have a lower health-related quality of life. We collaborated with an international task force to develop and validate the novel Phoenix criteria for sepsis and septic shock in children, which were published in two high-impact articles in JAMA and are now the reference standard for diagnosing pediatric sepsis around the world.8,9 The criteria are based on the Phoenix Sepsis Score (PSS), which we developed using a data- driven approach and >3.6 million patient records and include information for four organ dysfunctions. In order to maximize the impact of the Phoenix criteria for pediatric sepsis, several knowledge gaps must be addressed. In this study we will: evaluate the prognostic accuracy of the Phoenix sepsis criteria and the PSS before and after the COVID-19 pandemic and in the setting of specific organisms and infectious syndromes as well as varying vaccination status of at-risk children (SA 1); derive and validate sepsis trajectories based on the changes in the PSS over time that can help inform clinical decision-making (SA 2); prospectively validate the Phoenix sepsis criteria and the PSS overall and in high-risk patient subgroups (SA 3); and design and implement generalizable clinical workflows that maximize the impact of the Phoenix sepsis criteria and PSS trends (SA 4). We will leverage and expand our existing dataset by adding 2 new sites, 5 additional years of data from each site, and new data elements including vaccination records. We will also conduct a prospective study at four sites to validate the performance of the Phoenix criteria as CDS tools. We have enhanced our accomplished investigative team by adding new sites and expertise in human-computer interaction, CDS tool design, and pediatric hospital medicine. We expect the results of this proposal to have a powerful and sustained impact on the science of pediatric sepsis and ultimately improve sepsis recognition, accelerate appropriate effective treatment, decrease unnecessary treatment, and improve the outcomes of children with sepsis around the world.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	6	10/30/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $679,451 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	001	6	8/18/2026	NON-COMPETING CONTINUATION	$679,451
2026	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	4	2/26/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $679,451

Issue Date FY: 2025 ( Subtotal = $782,003 )
2025	2025	THE REGENTS OF THE UNIV. OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	5	8/26/2025	COMPETING CONTINUATION	$782,003
														Subtotal = $782,003

Issue Date FY: 2024 ( Subtotal = $636,265 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	4	8/20/2024	NON-COMPETING CONTINUATION	$636,265
														Subtotal = $636,265

Issue Date FY: 2023 ( Subtotal = $871,237 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	2	11/3/2022	SUPPLEMENT FOR EXPANSION	$237,623
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	001	3	8/9/2023	NON-COMPETING CONTINUATION	$633,614
														Subtotal = $871,237

Issue Date FY: 2022 ( Subtotal = $610,370 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	2	8/16/2022	NON-COMPETING CONTINUATION	$610,370
														Subtotal = $610,370

Issue Date FY: 2021 ( Subtotal = $1,001,721 )
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	000	1	8/31/2021	NEW	$754,556
2021	2021	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Child Health and Human Development Extramural Research	001	1	9/21/2021	SUPPLEMENT FOR EXPANSION	$247,165
														Subtotal = $1,001,721

Grand Total All Awards = $4,581,047

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Novel Pediatric Sepsis Criteria and Clinical Decision Support Tools

Award Number: R01HD105939

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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