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The Impact of Opioids on Health Outcomes for Hospitalized Infants

Award Number: R01HD105656
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2022
PERIOD OF PERFORMANCE END DATE: 02/28/2027

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The Impact of Opioids on Health Outcomes for Hospitalized Infants - PROJECT SUMMARY Caring for hospitalized infants requires a comprehensive pain control program aimed at reducing and preventing pain. While opioids are commonly used when an infant undergoes a painful procedure, opioids can increase the risk of short- and long-term morbidity. The duration and type of opioids used for hospitalized infants varies widely between institutions and such wide variations could impact early childhood development and overall healthcare utilization. In this study, we will create a novel clinical and developmental dataset by merging the Pediatric Health Information System (PHIS) and the California Perinatal Quality Care Collaborative (CPQCC). This merged dataset will be the first large retrospective, multi-center cohort representing diverse populations of critically ill, hospitalized infants linking their in-hospital data with long-term neurodevelopmental outcomes. Using this novel dataset, we will (1) identify variations in opioid use associated with neurodevelopmental disability and long-term resource utilization for high-risk infants, (2) quantify cumulative opioid dosing received associated with neurodevelopmental disability for high-risk infants, and (3) quantify differences in healthcare utilization and costs associated with high vs. low opioid use among high-risk infants. The expected outcome is a comprehensive understanding of the variations in opioid use for high-risk infants and its impact on neurodevelopment and healthcare utilization. Results will lead to interventions for hospitalized infants aimed at minimizing variation in pain control and will also inform policymakers of a previously unrecognized infant population in need of increased resources to improve clinical and developmental outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $590,678 )
2026	2026	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	5	2/26/2026	NON-COMPETING CONTINUATION	$590,678
														Subtotal = $590,678

Issue Date FY: 2025 ( Subtotal = $600,482 )
2025	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Child Health and Human Development Extramural Research	001	4	4/10/2025	NON-COMPETING CONTINUATION	$60,049
2025	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	4	2/12/2025	NON-COMPETING CONTINUATION	$540,433
														Subtotal = $600,482

Issue Date FY: 2024 ( Subtotal = $605,870 )
2024	2024	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Child Health and Human Development Extramural Research	001	3	4/30/2024	NON-COMPETING CONTINUATION	$55,080
2024	2024	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	3	2/29/2024	NON-COMPETING CONTINUATION	$550,790
														Subtotal = $605,870

Issue Date FY: 2023 ( Subtotal = $622,441 )
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	2	2/21/2023	NON-COMPETING CONTINUATION	$622,441
														Subtotal = $622,441

Issue Date FY: 2022 ( Subtotal = $666,735 )
2022	2022	CHILDRENS HOSPITAL LOS ANGELES	4650 SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	1	2/11/2022	NEW	$666,735
														Subtotal = $666,735

Grand Total All Awards = $3,086,206

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The Impact of Opioids on Health Outcomes for Hospitalized Infants

Award Number: R01HD105656

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2022

PERIOD OF PERFORMANCE END DATE: 02/28/2027

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