Monday, October 6, 2025 10/6/2025

Tongue maturation deficits in a mouse model of Down syndrome

Award Number: R01HD104640
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2021
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Tongue maturation deficits in a mouse model of Down syndrome - Abstract Atypical and delayed oromotor development is a well-known clinical aspect of Down syndrome (DS) and contributes to devastating challenges in speech, feeding, and swallowing. These challenges can affect the majority of individuals with DS, with profound consequences for quality of life and health. The tongue and brainstem are both complex systems that undergo rapid changes during early postnatal development and are critical for speech and swallowing. However, the central and peripheral changes occurring in early childhood that permit postnatal expansion in movement and function of the tongue are poorly understood in typical development and in DS. This proposal is for an administrative supplement to the INCLUDE-funded parent grant, “Tongue maturation deficits in a mouse model of Down syndrome”, which tests the central hypothesis that DS is associated with developmental delays in maturation of the tongue neuromuscular system. The parent grant uses the Ts65Dn mouse model of DS exclusively to generate normative data for the study of tongue and brainstem maturation at early postnatal ages and will determine how DS impacts lingual development. This is achieved through behavioral and immunofluorescence studies of tongue muscles and brainstem. However, new animal models of DS with superior genetic verisimilitude to DS have now become available. The proposed supplement work will expand a key subset of the parent grant goals to incorporate the new Ts66Yah mouse model of DS (Supplement Aim 1a). This supplement aim will further the science underlying both typical and delayed lingual maturation. As such, this work will provide basic knowledge for future efforts to develop biologically based approaches for successful resolution of pediatric oromotor disorders that impact children with DS. These goals will establish an experimental framework to advance biologically informed treatments for developmental speech, feeding, and swallowing disorders. This application addresses the NIH INCLUDE Component 1: Targeted high risk – high reward basic science studies in areas highly relevant to DS.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $618,730 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Child Health and Human Development Extramural Research	003	3	8/14/2025	SUPPLEMENT FOR EXPANSION	$182,643
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Child Health and Human Development Extramural Research	002	3	8/12/2025	NON-COMPETING CONTINUATION	$436,087
2025	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Child Health and Human Development Extramural Research	001	2	3/20/2025	EXTENSION WITH OR WITHOUT FUNDS	$141,807
2025	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Child Health and Human Development Extramural Research	000	1	3/20/2025	NEW	-$141,807
														Subtotal = $618,730

Issue Date FY: 2024 ( Subtotal = $438,647 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Child Health and Human Development Extramural Research	000	2	8/21/2024	EXTENSION WITH OR WITHOUT FUNDS	$438,647
														Subtotal = $438,647

Issue Date FY: 2021 ( Subtotal = $1,308,661 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Child Health and Human Development Extramural Research	000	1	9/22/2021	NEW	$1,308,661
														Subtotal = $1,308,661

Grand Total All Awards = $2,366,038

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Tongue maturation deficits in a mouse model of Down syndrome

Award Number: R01HD104640

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2021

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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