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The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.

Award Number: R01HD104297
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/20/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors. - ABSTRACT Neighborhood disadvantage is a potent predictor of youth risk-taking and aggressive antisocial behaviors (ASB). This association with youth ASB emerges early in life and increases over time. Understanding how neighborhood disadvantage leads to youth ASB thus constitutes a critical public health need. To date, however, the biological mechanism(s) through which disadvantage influences youth ASB remain unclear. The proposed R01 will explore methylation as a key biological pathway underlying the association between neighborhood disadvantage and youth ASB. We specifically postulate that neighborhood disadvantage and its social and physical `active ingredients' (e.g., harsh parenting, exposure to community violence, and toxicant exposure) will predict youth ASB via methylomic alterations, and that these associations will persist over any genetic confounds. To examine this possibility, we will generate methylation data from blood and/or saliva at four assessment waves (neonatal, middle childhood, and early and mid-adolescence) in a discovery sample of 500 adolescent twin pairs (1,000 twins) residing in modestly-to-severely disadvantaged neighborhoods. We then propose to replicate the phenotypic associations in an independent sample of 237 singleton youth living in poverty with methylation data from blood and/or saliva at three assessment waves (neonatal, middle childhood, and mid-adolescence). As our final step, we will leverage the focus on twin pairs in our Discovery twin sample to evaluate whether the replicated methylomic associations are environmental and/or genetic in origin. In short, the proposed R01 will not only identify neighborhood-induced methylomic alterations in two independent samples of impoverished youth, but will also illuminate the environmental and/or genetic etiology of those replicated alterations. In this way, we will move the field of social and environmental epigenetics forward in several areas.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $572,329 )
2025	2025	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	000	5	5/1/2025	NON-COMPETING CONTINUATION	$572,329
														Subtotal = $572,329

Issue Date FY: 2024 ( Subtotal = $562,735 )
2024	2024	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	000	4	5/22/2024	NON-COMPETING CONTINUATION	$562,735
														Subtotal = $562,735

Issue Date FY: 2023 ( Subtotal = $578,463 )
2023	2023	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	000	3	5/23/2023	NON-COMPETING CONTINUATION	$578,463
														Subtotal = $578,463

Issue Date FY: 2022 ( Subtotal = $575,787 )
2022	2022	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	000	2	5/20/2022	NON-COMPETING CONTINUATION	$575,787
														Subtotal = $575,787

Issue Date FY: 2021 ( Subtotal = $603,248 )
2021	2021	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Child Health and Human Development Extramural Research	000	1	7/20/2021	NEW	$603,248
														Subtotal = $603,248

Grand Total All Awards = $2,892,562

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The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.

Award Number: R01HD104297

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/20/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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