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Quantifying body shape in pediatric clinical research

Award Number: R01HD103885
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/09/2021
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Quantifying body shape in pediatric clinical research - Project Summary/Abstract. Excess adiposity is associated with metabolic changes that significantly increase the risk of developing 13 types of cancer. It is estimated that up to 20% of cancer cases are caused by obesity and that obesity prevention can play a significant role in the reduction of cancer incidence. Among obese adolescents, the most rapid weight gain has been shown to occur between 2 and 6 years of age. Despite clear connections between these factors and obesity risk, the study of obesity in early childhood is limited by the lack of body composition technologies appropriate for this age range. The long term goal of the Shape Up! Keiki is 1) to provide pediatric phenotype descriptors of health derived from detailed body shape scans from high-speed and high depth resolution 3D cameras, and 2) to provide the tools to visualize and quantify body shape in research and clinical practice. Our approach addresses technology issues that have hindered body composition research in this age range including participants' inability to hold still, follow directions, small body size, and rapid fluid shifts. To develop our body composition models, we will recruit 360 ethnically-diverse children from birth to 5 years stratified by sex and BMI-Z. Our central hypothesis is that optical estimates of body composition suitably represent a 5-compartment (5C) body composition model for studies of adiposity and health in young children and are superior to that of simple anthropometry and demographics. Our specific aims and subaims are as follows: 1) identify the statistical shape descriptors from 3DO scans that best represent 5-compartment body composition in an ethnically-diverse pediatric population, 1(a) identify the relationships that best link 3DO shape descriptors of body subregions (arms, legs, trunk), and matching volumes and body composition measures, 1(b) calibrate automated 3DO anthropometry to clinically relevant girths and lengths, Exploratory) identify accessible combinations of 3DO and TBW that can be calibrated to criterion 5C measures of fat and hydration, 2) identify the factors that define the precision of accessible 3D optical body composition estimates to monitor change in body composition and metabolic health interventions, 3) contrast the association of body shape, 3DO, and 5C criterion body composition to pediatric health indicators including clinically relevant exposures (SES, nursing duration, birth method, nutrition) and development. The rationale for this study is that early life access to accurate body composition data will enable identification of factors that increase obesity, metabolic disease, and cancer risk, and provide a means to target interventions to those that would benefit. The expected outcome is that our findings would be immediately applicable to accessible gaming and imaging sensors found on modern computers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $623,728 )
2025	2025	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Child Health and Human Development Extramural Research	000	5	7/28/2025	NON-COMPETING CONTINUATION	$623,728
														Subtotal = $623,728

Issue Date FY: 2024 ( Subtotal = $617,491 )
2024	2024	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Child Health and Human Development Extramural Research	000	4	5/23/2024	NON-COMPETING CONTINUATION	$617,491
														Subtotal = $617,491

Issue Date FY: 2023 ( Subtotal = $616,871 )
2023	2023	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Child Health and Human Development Extramural Research	000	3	6/1/2023	NON-COMPETING CONTINUATION	$616,871
														Subtotal = $616,871

Issue Date FY: 2022 ( Subtotal = $632,270 )
2022	2022	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Child Health and Human Development Extramural Research	000	2	6/9/2022	NON-COMPETING CONTINUATION	$632,270
														Subtotal = $632,270

Issue Date FY: 2021 ( Subtotal = $659,305 )
2021	2021	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Child Health and Human Development Extramural Research	000	1	8/9/2021	NEW	$659,305
														Subtotal = $659,305

Grand Total All Awards = $3,149,665

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Quantifying body shape in pediatric clinical research

Award Number: R01HD103885

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/09/2021

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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