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Genomic and Environmental Determinants of Infant Deaths in San Diego County in 2015-2022

Award Number: R01HD101540
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Infant mortality is tracked annually worldwide. Knowledge of causes of infant mortality shapes public health policy and prioritizes diseases for investments in surveillance, intervention and medical research. As a result, rates of many causes of infant mortality have declined significantly over the past 50 years. The proposed research team has pioneered a new way to decrease infant morbidity and mortality associated with 14,000 genetic diseases, called genomic medicine: In it, genome sequencing can provide a genetic disease diagnosis in as little as 19 hours. Early genetic disease diagnosis in seriously ill infants allows empiric initial treatment to be replaced with specific evidence-based treatment for that condition. In 9 studies of 681 seriously ill children, genomic sequencing diagnosed 31%, 21% had consequent changes in treatment, and 13% had changes in outcome. As a result, genomic medicine is gaining broad acceptance in seriously ill infants. However, for genomic medicine to decrease infant morbidity and mortality maximally and to anticipate the value of genetic diagnoses, it is critical to determine the leading genetic causes of infant mortality in the context of other environmental factors. We propose to use genome sequencing and semi-automated interpretation to identify genetic diseases associated with 1,000 infant deaths in San Diego County between 2015 and 2022 and to evaluate potential environmental contributions to those same infant deaths. We will identify potentially preventable infant deaths by determining those deaths associated with specific genetic diseases for which targeted interventions are known to reduce mortality. This new knowledge will enable policymakers, researchers, and clinicians to prioritize those diseases for investments in new, life-saving interventions and treatments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $593,337 )
2024	2024	RADY CHILDREN'S HOSPITAL RESEARCH CENTER	3020 CHILDRENS WAY # 5129	SAN DIEGO	CA	92123	SAN DIEGO	USA	Child Health and Human Development Extramural Research	000	5	1/22/2024	NON-COMPETING CONTINUATION	$593,337
														Subtotal = $593,337

Issue Date FY: 2023 ( Subtotal = $685,712 )
2023	2023	RADY CHILDREN'S HOSPITAL RESEARCH CENTER	3020 CHILDRENS WAY # 5129	SAN DIEGO	CA	92123	SAN DIEGO	USA	Child Health and Human Development Extramural Research	000	4	1/20/2023	NON-COMPETING CONTINUATION	$685,712
														Subtotal = $685,712

Issue Date FY: 2022 ( Subtotal = $701,359 )
2022	2022	RADY CHILDREN'S HOSPITAL RESEARCH CENTER	3020 CHILDRENS WAY # 5129	SAN DIEGO	CA	92123	SAN DIEGO	USA	Child Health and Human Development Extramural Research	000	3	1/10/2022	NON-COMPETING CONTINUATION	$631,223
2022	2022	RADY CHILDREN'S HOSPITAL RESEARCH CENTER	3020 CHILDRENS WAY # 5129	SAN DIEGO	CA	92123	SAN DIEGO	USA	Child Health and Human Development Extramural Research	001	3	4/19/2022	NON-COMPETING CONTINUATION	$70,136
														Subtotal = $701,359

Issue Date FY: 2021 ( Subtotal = $717,518 )
2021	2021	RADY CHILDREN'S HOSPITAL RESEARCH CENTER	3020 CHILDRENS WAY # 5129	SAN DIEGO	CA	92123	SAN DIEGO	USA	Child Health and Human Development Extramural Research	000	2	1/28/2021	NON-COMPETING CONTINUATION	$658,946
2021	2021	RADY CHILDREN'S HOSPITAL RESEARCH CENTER	3020 CHILDRENS WAY # 5129	SAN DIEGO	CA	92123	SAN DIEGO	USA	Child Health and Human Development Extramural Research	002	2	3/26/2021	NON-COMPETING CONTINUATION	$0
2021	2021	RADY CHILDREN'S HOSPITAL RESEARCH CENTER	3020 CHILDRENS WAY # 5129	SAN DIEGO	CA	92123	SAN DIEGO	USA	Child Health and Human Development Extramural Research	001	2	2/3/2021	NON-COMPETING CONTINUATION	$58,572
														Subtotal = $717,518

Issue Date FY: 2020 ( Subtotal = $766,419 )
2020	2020	RADY CHILDREN'S HOSPITAL RESEARCH CENTER	3020 CHILDRENS WAY # 5129	SAN DIEGO	CA	92123	SAN DIEGO	USA	Child Health and Human Development Extramural Research	000	1	3/18/2020	NEW	$766,419
														Subtotal = $766,419

Grand Total All Awards = $3,464,345

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Genomic and Environmental Determinants of Infant Deaths in San Diego County in 2015-2022

Award Number: R01HD101540

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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