Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Effects of early-life nutritional supplementation on the brains, bodies, and behaviors of Ghanaian youths in middle adolescence

Award Number: R01HD099811
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/04/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2030

Group Awards By:

View Award Description

Effects of early-life nutritional supplementation on the brains, bodies, and behaviors of Ghanaian youths in middle adolescence - PROJECT ABSTRACT An estimated 250 million children in low- and middle-income countries are at risk of not fulfilling their developmental potential, partly due to undernutrition. The long-term goal of this proposal is to inform evidence- based programs and policies to support children and adolescents in Ghana and other low- and middle-income countries to grow and develop to their full potential. This proposal is to conduct a follow-up study of youth at 14-16 years whose mothers participated in a randomized controlled trial providing small-quantity lipid-based nutrient supplements (SQ-LNS) to pregnant women from ≤ 20 weeks of gestation through 6 months postpartum and to their infants from age 6 to 18 months (n = 440), comparing outcomes to youth from the control groups whose mothers received micronutrient capsules during pregnancy and postpartum (n = 880) without additional supplementation to the infants. Under protocol R01HD099811, we enrolled 979 children at 10-12 years in assessments of brain and body maturation, autonomic regulation, adrenocortical and adrenogonadal hormones, and behavioral and psychosocial functioning. Benefits of SQ-LNS, directly and in the context of home environment quality, were evident in white matter microstructure, height, pubertal development, and other measures. We seek to document the long-term effects of SQ-LNS on brain and nervous system development and biobehavioral functioning in middle adolescence, a pivotal period marking the onset of multiple mental and physical health problems. The specific aims are 1) To investigate the long- term effects of SQ-LNS on physical maturation, as seen in brain structure, height, and pubertal development; 2) To examine the emergent effects of SQ-LNS on brain function, autonomic regulation and hormonal activity in middle adolescence, both directly and in the context of quality of home environments; and 3) to show the neurobiological mechanisms through which SQ-LNS promotes psychosocial and cognitive competence and buffers the effects of disadvantaged environments on youth’s social-emotional difficulties. The hypotheses are that, compared to youth who did not receive early SQ-LNS, youth in the SQ-LNS group will H1) have better white matter microstructure, be taller, and have normatively timed pubertal milestones, and H2) evince stronger prefrontal cortex regulation of subcortical regions, more flexible autonomic regulation, and lower chronic cortisol levels, especially when raised in less advantaged home environments. Further, H3) intervention group differences in neurobiological structure and functioning are expected to mediate group differences in social-emotional development. This study will be the longest follow-up study in Africa of a RCT of pre- and post-natal nutritional supplementation covering most of the first 1000 days of life following conception. This study represents an unprecedented opportunity to examine the enduring and emergent effects in middle adolescence of a novel nutrient supplement in early life using a RCT design, and the underlying neural mechanisms of the effects of early nutrition on later adjustment and well-being.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $307,050 )
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	001	7	5/5/2026	NON-COMPETING CONTINUATION	$307,052
2026	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	5	2/12/2026	NON-COMPETING CONTINUATION	-$2
														Subtotal = $307,050

Issue Date FY: 2025 ( Subtotal = $563,445 )
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	6	7/31/2025	COMPETING CONTINUATION	$337,539
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	003	6	9/19/2025	SUPPLEMENT FOR EXPANSION	$225,906
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	002	6	9/17/2025	SUPPLEMENT FOR EXPANSION	-$225,906
2025	2025	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	001	6	7/31/2025	SUPPLEMENT FOR EXPANSION	$225,906
														Subtotal = $563,445

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	5	11/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $495,756 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	5	7/14/2023	NON-COMPETING CONTINUATION	$495,756
														Subtotal = $495,756

Issue Date FY: 2022 ( Subtotal = $582,240 )
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	4	7/21/2022	NON-COMPETING CONTINUATION	$506,351
2022	2022	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	001	4	7/24/2022	SUPPLEMENT FOR EXPANSION	$75,889
														Subtotal = $582,240

Issue Date FY: 2021 ( Subtotal = $777,230 )
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	3	7/15/2021	NON-COMPETING CONTINUATION	$544,474
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	001	3	8/13/2021	SUPPLEMENT FOR EXPANSION	$75,889
2021	2021	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	002	3	9/17/2021	SUPPLEMENT FOR EXPANSION	$156,867
														Subtotal = $777,230

Issue Date FY: 2020 ( Subtotal = $546,223 )
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	001	2	6/24/2020	NON-COMPETING CONTINUATION	$505,183
2020	2020	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	002	2	9/14/2020	SUPPLEMENT FOR EXPANSION	$41,040
2020	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	1	1/24/2020	NEW	$0
														Subtotal = $546,223

Issue Date FY: 2019 ( Subtotal = $565,190 )
2019	2019	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Child Health and Human Development Extramural Research	000	1	9/4/2019	NEW	$565,190
														Subtotal = $565,190

Grand Total All Awards = $3,837,134

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Effects of early-life nutritional supplementation on the brains, bodies, and behaviors of Ghanaian youths in middle adolescence

Award Number: R01HD099811

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/04/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer