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Executive Function Outcome Measures for Young Children with Down Syndrome

Award Number: R01HD099150
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/13/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Executive Function Outcome Measures for Young Children with Down Syndrome - Down syndrome (DS) is the most common neurogenetic syndrome associated with intellectual disability, occurring in approximately 1:691 live births (Parker et al., 2010). Recent approaches to treatment in DS and other neurogenetic disorders have begun to focus on the earliest part of the lifespan. This type of targeted early treatment work will require highly sensitive and psychometrically sound outcome measures to demonstrate effects on early developmental trajectories in DS. However, young children with DS show phenotype-specific delays in motor development and early communication, which could confound the reliability and validity of early developmental assessments in the critical cognitive domain of executive function (EF). Therefore, rigorous psychometric validation of EF assessments is needed to advance treatment science for young children with DS. In this study, 210 young children with DS (between 2.5 and 7.99 years) will be assessed at four waves of data collection to establish reliability, validity, internal consistency, and sensitivity to change in the proposed battery of assessments. A promising set of laboratory assessments has been selected to measure various aspects of EF. The proposed measures will minimize phenotype-related confounds that threaten the reliability and/or the validity of early cognitive assessment in DS. Advanced quantitative analytic approaches utilizing latent variable models within a structural equation modeling framework will be used to investigate the psychometric properties of the proposed measures. Project outcomes will strengthen treatment science for young children with DS and contribute to the critical effort to improve developmental outcomes in this population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$49,625 )
2026	2023	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Child Health and Human Development Extramural Research	000	5	12/15/2025	NON-COMPETING CONTINUATION	-$49,625
														Subtotal = -$49,625

Issue Date FY: 2023 ( Subtotal = $560,075 )
2023	2023	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Child Health and Human Development Extramural Research	000	5	7/3/2023	NON-COMPETING CONTINUATION	$560,075
2023	2021	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Child Health and Human Development Extramural Research	001	3	9/7/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $560,075

Issue Date FY: 2022 ( Subtotal = $564,683 )
2022	2022	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Child Health and Human Development Extramural Research	000	4	6/27/2022	NON-COMPETING CONTINUATION	$564,683
														Subtotal = $564,683

Issue Date FY: 2021 ( Subtotal = $1,440,951 )
2021	2021	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Child Health and Human Development Extramural Research	000	3	6/28/2021	NON-COMPETING CONTINUATION	$565,166
2021	2021	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Child Health and Human Development Extramural Research	001	3	9/21/2021	SUPPLEMENT FOR EXPANSION	$875,785
														Subtotal = $1,440,951

Issue Date FY: 2020 ( Subtotal = $577,958 )
2020	2020	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Child Health and Human Development Extramural Research	000	2	7/14/2020	NON-COMPETING CONTINUATION	$577,958
														Subtotal = $577,958

Issue Date FY: 2019 ( Subtotal = $673,186 )
2019	2019	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Child Health and Human Development Extramural Research	000	1	9/13/2019	NEW	$673,186
														Subtotal = $673,186

Grand Total All Awards = $3,767,228

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Executive Function Outcome Measures for Young Children with Down Syndrome

Award Number: R01HD099150

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/13/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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