Monday, December 22, 2025 12/22/2025

Estracellular Vesicles as Non-Invasive Predictors of Antidepressant Outcomes in Pediatric Anxiety

Award Number: R01HD098757
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/17/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2025

Group Awards By:

View Award Description

Estracellular Vesicles as Non-Invasive Predictors of Antidepressant Outcomes in Pediatric Anxiety - PROJECT SUMMARY Anxiety disorders are among the most common psychiatric conditions in children and adolescents with a prevalence of more than 10%. Left untreated, pediatric patients with anxiety disorders suffer physical, emotional, academic, and social impairment, and these disorders increase the likelihood of secondary anxiety disorders, major depressive disorder and other psychiatric conditions in adulthood. Selective-serotonin reuptake inhibitors (SSRIs) are the first-line psychopharmacologic treatment for these conditions, but may take up to 8 weeks to produce responses—which only occur in 50-60% of youth. Further, SSRI-related adverse effects emerge early in the course of treatment, decrease the likelihood of success and increase the likelihood of medication discontinuation. These significant side effects include gastrointestinal symptoms and activation—a hyperarousal event characterized by specific symptoms including an increase in activity, impulsivity, disinhibition, restlessness, and insomnia. Today, there is no way to predict, based on clinical or biological characteristics which children and adolescents will respond to an SSRI or who will develop treatment-limiting adverse effects—a significant concern of patients and their families. The goal of this proposal is to advance the treatment of pediatric anxiety disorders by examining predictive markers of SSRI treatment response and SSRI-related gastrointestinal symptoms and activation. This proposal builds upon our significant finding that 5 lipid classes derived from plasma extracellular vesicles (EVs) predict SSRI response in anxious youth. This application proposes to replicate our preliminary study in a large, multi- site, double-blind placebo-controlled trial and utilizes synchronized methods for biospecimen collection and outcome measurement. This proposal will also evaluate a specific subpopulation of EVs—L1CAM(+) EVs— which are enriched in cargoes of neuronal origin, providing a targeted, non-invasive assessment of the molecular milieu of the CNS. The line of inquiry is novel to precision medicine/child and adolescent mental health, and has the potential to propel the treatment of anxiety disorders in youth while increasing the safety of SSRI treatment, by predicting SSRI-related side effects.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$377,328 )
2026	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	000	5	12/16/2025	NON-COMPETING CONTINUATION	-$377,328
														Subtotal = -$377,328

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	000	5	12/3/2024	NON-COMPETING CONTINUATION	$0
2025	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	001	5	6/4/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $454,389 )
2024	2024	CINCINNATI UNIV OF	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	000	5	8/22/2024	NON-COMPETING CONTINUATION	$454,389
														Subtotal = $454,389

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	000	4	8/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $471,436 )
2022	2022	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	000	4	6/17/2022	NON-COMPETING CONTINUATION	$471,436
														Subtotal = $471,436

Issue Date FY: 2021 ( Subtotal = $473,506 )
2021	2021	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	000	3	9/23/2021	NON-COMPETING CONTINUATION	$473,506
														Subtotal = $473,506

Issue Date FY: 2020 ( Subtotal = $487,628 )
2020	2020	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	000	2	7/27/2020	NON-COMPETING CONTINUATION	$487,628
														Subtotal = $487,628

Issue Date FY: 2019 ( Subtotal = $530,499 )
2019	2019	UNIVERSITY OF CINCINNATI	2600 CLIFTON AVE	CINCINNATI	OH	45220	HAMILTON	USA	Child Health and Human Development Extramural Research	000	1	7/17/2019	NEW	$530,499
														Subtotal = $530,499

Grand Total All Awards = $2,040,130

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Estracellular Vesicles as Non-Invasive Predictors of Antidepressant Outcomes in Pediatric Anxiety

Award Number: R01HD098757

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/17/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer