Friday, May 9, 2025 5/9/2025

Effect?of?Soluble?Corn?Fiber?supplementation?for?1?year?on?bone?metabolism?in?adolescents (MetA-Bone Trial)

Award Number: R01HD098589
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Effect?of?Soluble?Corn?Fiber?supplementation?for?1?year?on?bone?metabolism?in?adolescents (MetA-Bone Trial) - Project Summary This Administrative Supplement for Research on Dietary Supplements is for year 5 of the funded parent grant “MetA-Bone Trial” (# 5R01HD098589-04), a randomized double-blinded placebo- controlled trial to determine the effects of 1-year soluble corn fiber (SCF) supplementation on bone metabolism in children. This proposal will expand our research on the effects of SCF (a prebiotic fiber) on the gut microbiome diversity and how this is associated with changes in body composition inflammatory biomarkers in this sample. A total of 110 participants have been recruited so far, of which >75% are minority (68% are Hispanics and 8% are Blacks). Fecal, 24-h urine, and blood samples are being collected and saved in our biorepository for future analysis. Evidence shows that the gut microbiome is associated with obesity, which is particularly higher among Hispanics and Blacks. Obesity has been associated with a different bacteria composition (less bacterial diversity and reduced Bacteroidetes/Firmicutes ratio). Diets low in fiber (which is very common in US children) also changes the microbiota. These changes in the gut could lead to chronic, low-grade inflammation. This could be reversed or improved by prebiotic fiber supplementation. The only 2 studies to date supplementing children with inulin (another type of prebiotic fiber) found significant decreases in body weight z-score, percent body fat, IL-6, and gut microbiome composition. However, to our knowledge, there are no studies evaluating the effects of SCF on gut microbiome diversity, body composition, and in inflammatory biomarkers in children or in minorities. The aims of this administrative supplement are: (1) Evaluate the changes in the gut microbiome diversity (through Shannon, Simpson, and Inverse Simpson indices, measures of richness and evenness; new analyses) with 1-year SCF supplementation and how this is associated with changes in body composition (% fat mass and lean mass from DXA scan); (2) Evaluate the changes in inflammatory biomarkers (fecal calproctectin, urinary IL-6, and serum CRP; new analyses) with 1-year SCF supplementation and if these changes are mediated by changes in body composition; and (3) Engage 2 graduate students in training and mentorship to build future research capacity for studying the role of dietary supplements in health and disease prevention. If successful, the results from this application will improve our understanding of the role of SCF on gut microbiome, body composition, and inflammation. This could lead to designing interventions to promote supplementing diets with SCF for improving health and potentially preventing chronic conditions associated with excessive fat mass and low-grade inflammation in minority children and adolescents.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $721,121 )
2023	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	002	5	7/10/2023	SUPPLEMENT FOR EXPANSION	$143,168
2023	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	001	5	5/16/2023	SUPPLEMENT FOR EXPANSION	$72,582
2023	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	000	5	5/15/2023	NON-COMPETING CONTINUATION	$505,371
														Subtotal = $721,121

Issue Date FY: 2022 ( Subtotal = $728,696 )
2022	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	001	4	6/9/2022	NON-COMPETING CONTINUATION	$534,728
2022	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	002	4	6/10/2022	SUPPLEMENT FOR EXPANSION	$133,275
2022	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	000	3	1/4/2022	SUPPLEMENT FOR EXPANSION	$60,693
														Subtotal = $728,696

Issue Date FY: 2021 ( Subtotal = $553,337 )
2021	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	000	3	6/2/2021	NON-COMPETING CONTINUATION	$553,337
														Subtotal = $553,337

Issue Date FY: 2020 ( Subtotal = $579,510 )
2020	2020	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	000	2	6/10/2020	NON-COMPETING CONTINUATION	$579,510
														Subtotal = $579,510

Issue Date FY: 2019 ( Subtotal = $591,671 )
2019	2019	FLORIDA INTERNATIONAL UNIVERSITY	11200 S W 8TH ST MARC 430	MIAMI	FL	33199	MIAMI-DADE	USA	Child Health and Human Development Extramural Research	000	1	6/11/2019	NEW	$591,671
														Subtotal = $591,671

Grand Total All Awards = $3,174,335

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Effect?of?Soluble?Corn?Fiber?supplementation?for?1?year?on?bone?metabolism?in?adolescents (MetA-Bone Trial)

Award Number: R01HD098589

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer