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Impact of sensory impairments on movement in children with cerebral palsy

Award Number: R01HD095663
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/13/2018
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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Impact of sensory impairments on movement in children with cerebral palsy - PROJECT SUMMARY Cerebral palsy (CP) is the most common pediatric neurological disorder. CP is caused by damage to brain areas during development. CP results in weakness, altered tone and abnormal coordination. In unilateral spastic CP (USCP), the damage has a unilateral predominance. Although CP is defined as a motor disability, approximately 80% of people with USCP have deficits in sensation that limit the extent of rehabilitation. There is a poor understanding of how the sensory and motor systems interact in children with USCP. Impairments in motor and sensory function have largely been studied in isolation (rather than together) in children with USCP, even though voluntary movement requires the integration of sensory and motor processing. Moreover, while the motor system is better-characterized, there is still a limited understanding of how the location, type, and size of a child’s lesion impacts sensorimotor processing. There is an urgent need to identify and quantify sensory factors that impair movement in children with USCP. Our long-term goal is to develop evidence-based ways to improve movement in children with USCP. The overall objective for this project is to determine how fine touch sensation and sensation of limb position contribute to movement deficits in children with USCP. To meet our goal, we must not only know how sensory systems impact impairment in movement, but we must determine how a child’s lesion and brain connectivity contributes to these impairments. Our central hypothesis is that sensory dysfunction plays a key role in the ability of children with USCP to engage in functional, skillful movements. We also hypothesize that damage to specific brain regions cause specific kinds of impairments. The rationale for the proposed work is that demonstration of a strong relationship between sensory impairments and movement deficits will steer the development of therapies that engage children in the use of sensory information during meaningful complex tasks, with the goal of boosting motor function. !


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	THE WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Child Health and Human Development Extramural Research	000	5	10/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $386,373 )
2022	2022	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Child Health and Human Development Extramural Research	000	5	5/27/2022	NON-COMPETING CONTINUATION	$386,373
														Subtotal = $386,373

Issue Date FY: 2021 ( Subtotal = $386,217 )
2021	2021	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Child Health and Human Development Extramural Research	000	4	6/3/2021	NON-COMPETING CONTINUATION	$386,217
														Subtotal = $386,217

Issue Date FY: 2020 ( Subtotal = $393,600 )
2020	2020	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Child Health and Human Development Extramural Research	000	3	5/28/2020	NON-COMPETING CONTINUATION	$393,600
														Subtotal = $393,600

Issue Date FY: 2019 ( Subtotal = $392,303 )
2019	2019	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Child Health and Human Development Extramural Research	001	2	5/28/2019	NON-COMPETING CONTINUATION	$392,303
2019	2018	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Child Health and Human Development Extramural Research	000	1	11/14/2018	NEW	$0
														Subtotal = $392,303

Issue Date FY: 2018 ( Subtotal = $414,498 )
2018	2018	WINIFRED MASTERSON BURKE MEDICAL RESEARCH INSTITUTE, INC, THE	785 MAMARONECK AVE	WHITE PLAINS	NY	10605	WESTCHESTER	USA	Child Health and Human Development Extramural Research	000	1	9/13/2018	NEW	$414,498
														Subtotal = $414,498

Grand Total All Awards = $1,972,991

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Impact of sensory impairments on movement in children with cerebral palsy

Award Number: R01HD095663

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/13/2018

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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