Tuesday, February 17, 2026 2/17/2026

Cortical and Cognitive Development Following Synthetic Progestin Exposure

Award Number: R01HD093907
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/08/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2025

Group Awards By:

View Award Description

Cortical and Cognitive Development Following Synthetic Progestin Exposure - The administration of synthetic progestins to pregnant women for the prevention of premature delivery has increased dramatically in recent years. Despite this increase, very little is known about the potential effects of synthetic progestins on the developing brain. Previous findings from rodent models suggest that progestins may play a role in the development of frontal cortex and the mesocortical dopamine system, a neurochemical pathway implicated in Attention Deficit Hyperactivity Disorder (ADHD). The objective of this proposal is to examine the effects of exposure to the synthetic progestin, 17α hydroxyprogesterone caproate in the development of the mesocortical dopamine pathway, the mesocortical serotonin pathway, and subsequent complex cognitive behaviors mediated by these circuits using a rodent model. Aim 1 will utilize HPLC/Mass Spec to quantify 17P levels in blood and brain following the administration of behaviorally-effective doses. Aim 2 will test the hypothesis that exposure to 17P during development will alter the number of dopaminergic cells in the midbrain ventral tegmental area, the number of serotonergic cells in the raphe nuclei, and will alter the density of dopaminergic and serotonergic fibers within the medial prefrontal and orbitofrontal cortex. Aim 3 will test the hypothesis that exposure to 17P during postnatal life will alter cognitive and executive function behaviors mediated by these pathways. Specifically, cognitive flexibility, attentional processing and sensorimotor gating, behavioral inhibition/impulsivity, impulsive decision making, hyperactivity, and risk taking behavior will be assessed in adolescence and adulthood in rats exposed to 17P during development. Results from these animal studies would vastly increase our knowledge about the potential effects of progestin exposure to generate specific hypotheses for future research regarding outcomes in children exposed in utero.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$500,884 )
2026	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	1400 WASHINGTON AVE	ALBANY	NY	12222	ALBANY	USA	Child Health and Human Development Extramural Research	000	5	12/15/2025	NON-COMPETING CONTINUATION	-$500,884
														Subtotal = -$500,884

Issue Date FY: 2023 ( Subtotal = $317,117 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	1400 WASHINGTON AVE	ALBANY	NY	12222	ALBANY	USA	Child Health and Human Development Extramural Research	000	5	6/20/2023	NON-COMPETING CONTINUATION	$317,117
														Subtotal = $317,117

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	1400 WASHINGTON AVE	ALBANY	NY	12222	ALBANY	USA	Child Health and Human Development Extramural Research	000	4	7/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $317,251 )
2021	2021	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	1400 WASHINGTON AVE	ALBANY	NY	12222	ALBANY	USA	Child Health and Human Development Extramural Research	000	4	6/30/2021	NON-COMPETING CONTINUATION	$317,251
														Subtotal = $317,251

Issue Date FY: 2020 ( Subtotal = $323,860 )
2020	2020	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	1400 WASHINGTON AVE	ALBANY	NY	12222	ALBANY	USA	Child Health and Human Development Extramural Research	000	3	6/5/2020	NON-COMPETING CONTINUATION	$323,860
														Subtotal = $323,860

Issue Date FY: 2019 ( Subtotal = $326,317 )
2019	2019	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	1400 WASHINGTON AVE	ALBANY	NY	12222	ALBANY	USA	Child Health and Human Development Extramural Research	000	2	6/18/2019	NON-COMPETING CONTINUATION	$326,317
														Subtotal = $326,317

Issue Date FY: 2018 ( Subtotal = $314,856 )
2018	2018	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	1400 WASHINGTON AVE	ALBANY	NY	12222	ALBANY	USA	Child Health and Human Development Extramural Research	000	1	8/8/2018	NEW	$314,856
														Subtotal = $314,856

Grand Total All Awards = $1,098,517

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Cortical and Cognitive Development Following Synthetic Progestin Exposure

Award Number: R01HD093907

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/08/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer