Monday, November 3, 2025 11/3/2025

Perceptual motor interaction to improve bimanual coordination after stroke

Award Number: R01HD092481
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2018
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Perceptual motor interaction to improve bimanual coordination after stroke - PROJECT SUMMARY: Difficulty incorporating the weaker arm in everyday activities significantly contributes to impaired function and quality of life after stroke. Most prevalent rehabilitation approaches that focus on improving the unimanual performance of the weaker arm have had limited impact on weaker arm use and integration in the real world. In contrast to the unimanual focus of rehabilitation approaches, most tasks of daily living engage both arms in a highly coordinated and interactive manner. After unilateral stroke, the interactive coordination between the two arms is significantly impaired, even in patients with mild unimanual deficits, and is seldom remediated by unimanual training. Impaired bimanual coordination may greatly limit the integration of the weaker arm in daily activities, most of which are bimanual. Therefore, targeted training of bimanual coordination is necessary to achieve a more complete functional arm recovery. Designing effective training however requires a clear characterization of the fundamental deficits in how stroke survivors coordinate their arms, and how task demands influence that coordination. Further, to move in the direction of more definitive clinical investigations of bimanual training, it is important to identify factors that help explain individual variability in bimanual coordination after stroke. The proposed studies will determine: (a) how motor and perceptual task demands of a bimanual reaching task interact to influence coordination between arms in stroke survivors compared to age- matched controls, (b) the immediate effects of changing perceptual and motor task demands on bimanual coordination in stroke survivors and (c) the behavioral, neuroanatomic and neurophysiologic contributors to individual differences in bimanual coordination after stroke. The approach is strong in that it aims to determine the fundamental nature of bimanual control deficit(s) after stroke and then tests specific strategies to target the underlying deficit(s). Particularly innovative is the manipulation of perceptual task demands in a virtual environment to influence coordination between hands. Also, multimodal investigation to identify the contribution of lesion and neural connectivity to bimanual coordination in stroke survivors is novel. The proposed project is significant because it will provide fundamental understanding of brain-behavior relationship for bimanual coordination after stroke. This will advance the science of rehabilitation with a stronger clinical impact. For instance, identifying which patients have impaired bimanual coordination and who show improvements with perceptual cueing will provide crucial information for testing evidence-based targeted training of bimanual coordination in future studies. The results from this project will set the stage for future investigations aimed at the development of intervention protocols to improve bimanual coordination necessary for more complete functional arm recovery after stroke. Finally, this proposal takes us closer to achievement of the NIH mission to reduce the burden of neurological disorders and enhance the quality of life of people with disabilities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$75,562 )
2025	2023	JEFFERSON HEALTH CORPORATION	1101 MARKET ST STE 2400	PHILADELPHIA	PA	19107	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	5	9/11/2025	NON-COMPETING CONTINUATION	-$75,562
														Subtotal = -$75,562

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	ALBERT EINSTEIN HEALTHCARE NETWORK	5501 OLD YORK RD	PHILADELPHIA	PA	19141	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	5	5/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $375,210 )
2023	2023	ALBERT EINSTEIN HEALTHCARE NETWORK	5501 OLD YORK RD	PHILADELPHIA	PA	19141	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	5	5/10/2023	NON-COMPETING CONTINUATION	$375,210
														Subtotal = $375,210

Issue Date FY: 2022 ( Subtotal = $375,247 )
2022	2022	ALBERT EINSTEIN HEALTHCARE NETWORK	5501 OLD YORK RD	PHILADELPHIA	PA	19141	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	4	6/6/2022	NON-COMPETING CONTINUATION	$375,247
														Subtotal = $375,247

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	ALBERT EINSTEIN HEALTHCARE NETWORK	5501 OLD YORK RD	PHILADELPHIA	PA	19141	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	3	6/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $375,282 )
2020	2020	ALBERT EINSTEIN HEALTHCARE NETWORK	5501 OLD YORK RD	PHILADELPHIA	PA	19141	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	3	4/29/2020	NON-COMPETING CONTINUATION	$375,282
														Subtotal = $375,282

Issue Date FY: 2019 ( Subtotal = $375,316 )
2019	2019	ALBERT EINSTEIN HEALTHCARE NETWORK	5501 OLD YORK RD	PHILADELPHIA	PA	19141	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	2	6/3/2019	NON-COMPETING CONTINUATION	$375,316
														Subtotal = $375,316

Issue Date FY: 2018 ( Subtotal = $402,900 )
2018	2018	ALBERT EINSTEIN HEALTHCARE NETWORK	5501 OLD YORK RD	PHILADELPHIA	PA	19141	PHILADELPHIA	USA	Child Health and Human Development Extramural Research	000	1	5/15/2018	NEW	$402,900
														Subtotal = $402,900

Grand Total All Awards = $1,828,393

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Perceptual motor interaction to improve bimanual coordination after stroke

Award Number: R01HD092481

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2018

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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