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Oxytocin Ligand/Receptor Variants and Social Behavior

Award Number: R01HD089147
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/20/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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Oxytocin Ligand/Receptor Variants and Social Behavior - Project Summary/Abstract The brain neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important roles in altering neural circuits that regulate social behavior. These ligands regulate normative social function in a host of areas, including social attachment, parental behavior, aggression, and complex social cognition. In pathological brain/behavior conditions, many disorders are characterized by dramatic deficits in the social realm. Knowledge of the way OT and AVP alter cellular function in neurons has the potential to both identify mechanisms that produce social dysfunction and to design compounds that normalize cellular function and behavior. The present project takes advantage of the discovery of novel OT ligand structure, and variation in cellular receptors for OT and AVP in the marmoset, a species that exhibits social monogamy, infant care by males, and a family-like social structure. The first aim will characterize the effects of ligand diversity on the alteration of behavior in a variety of social domains by using in vivo behavioral pharmacology. These domains include male-female attachment, infant care, mate-defense aggression, and social cooperation/altruism. The second aim will quantify the receptor pharmacology and binding characteristics of the ligand variants with the cell membrane G protein-coupled receptors for these related ligands. The final aim will define the specific modifications in G protein-mediated cell signaling processes brought about by these ligands to determine if ligand variation that modifies social behavior does so through specific or `biased' activation of different signaling pathways. Collectively, these three aims will provide important insights into the ways in which neurons and behavior are modified by OT and AVP ligand variants, leading to enhanced knowledge of the neurobiology of social behavior. The project can point to potential options for designing neuropeptide ligand- receptor complexes that could serve as effective tools to treat social dysfunction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$61,986 )
2023	2020	UNIVERSITY OF NEBRASKA	6001 DODGE ST EAB 209	OMAHA	NE	68182	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	5	7/19/2023	NON-COMPETING CONTINUATION	-$61,986
														Subtotal = -$61,986

Issue Date FY: 2020 ( Subtotal = $301,899 )
2020	2020	UNIVERSITY OF NEBRASKA	6001 DODGE ST EAB 209	OMAHA	NE	68182	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	5	6/15/2020	NON-COMPETING CONTINUATION	$301,899
														Subtotal = $301,899

Issue Date FY: 2019 ( Subtotal = $301,978 )
2019	2019	UNIVERSITY OF NEBRASKA	6001 DODGE ST EAB 209	OMAHA	NE	68182	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	4	6/6/2019	NON-COMPETING CONTINUATION	$301,978
														Subtotal = $301,978

Issue Date FY: 2018 ( Subtotal = $302,044 )
2018	2018	UNIVERSITY OF NEBRASKA	6001 DODGE ST EAB 209	OMAHA	NE	68182	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	3	6/19/2018	NON-COMPETING CONTINUATION	$302,044
														Subtotal = $302,044

Issue Date FY: 2017 ( Subtotal = $302,107 )
2017	2017	UNIVERSITY OF NEBRASKA	6001 DODGE ST EAB 209	OMAHA	NE	68182	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	2	6/30/2017	NON-COMPETING CONTINUATION	$302,107
														Subtotal = $302,107

Issue Date FY: 2016 ( Subtotal = $321,466 )
2016	2016	UNIVERSITY OF NEBRASKA AT OMAHA	POST OFFICE BOX 688	OMAHA	NE	68101	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	1	8/18/2016	NEW	$321,466
														Subtotal = $321,466

Grand Total All Awards = $1,467,508

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Oxytocin Ligand/Receptor Variants and Social Behavior

Award Number: R01HD089147

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/20/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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