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Development of a Modular Soft Exosuit Platform Suitable for Community-Based Neurorehabilitation

Award Number: R01HD088619
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Stroke is the leading cause of long-term disability worldwide. However, despite extensive rehabilitation efforts, marked physical inactivity remains emblematic of individuals in the chronic phase of stroke recovery and contributes to poor health and quality of life. For poststroke rehabilitation to be better positioned to enable more physical activity, factors such as insufficient training dosage and poor ecological validity, which limit the effectiveness of clinic-based gait training, must be overcome. Community-based rehabilitation approaches can overcome these limitations; however, the amount of walking practice that they are able to leverage is inherently limited by the reduced walking capacity typical after stroke. Indeed, recent work has shown that despite producing some improvement in poststroke walking activity, individuals still remain largely sedentary after community-based walking programs. A critical need thus exists for rehabilitation technologies that bridge the gap between the clinic and the real world and facilitate the massed walking practice in salient contexts that is necessary to induce experience-dependent neuroplasticity. In response to this need, we are developing lightweight and unobtrusive soft wearable robots (exosuits) suitable for community-based rehabilitation after stroke. Exosuits use innovative force-transmitting, conformal textiles that anchor to the body and proximally-mounted, lightweight, cable-based actuation systems to generate assistive joint forces. Adaptive control algorithms that use signals from the minimum number of sensors direct the timing of assistance. These innovative wearable robots have the potential to increase an individual's capacity for community ambulation. Indeed, we have demonstrated through preliminary treadmill-based studies that an ankle-assisting exosuit produces paretic limb functional restoration in a manner that induces gait symmetry, reduces the energy cost of walking, and increases walking stability. In contrast to the rigid exoskeletons that have dominated the last half century, exosuits provide partial assistance through a lightweight platform (<3kg overall, including motors and batteries) that requires low power (<100W), can be used unilaterally, and does not impose an unnatural gait on the wearer. The exosuit technology is ideally suited to assisting the impaired gait of individuals poststroke who have residual walking capacity. This technology development-focused project seeks to build gait-restorative exosuits made of modular components that can be easily assembled to serve the heterogeneous needs of individuals poststroke. This project will optimize existing ankle, knee, and hip modules that have undergone >1000 hours of testing on >130 healthy and impaired subjects for use by persons poststroke in clinical- and community- settings. This work will be completed by a multidisciplinary team of engineers, clinicians, and researchers. Qualitative and quantitative data gathered from patients and other stakeholders will inform all development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	6	10/16/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	6	5/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $609,150 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	6	8/16/2021	NON-COMPETING CONTINUATION	$609,150
														Subtotal = $609,150

Issue Date FY: 2020 ( Subtotal = $621,583 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	5	7/8/2020	NON-COMPETING CONTINUATION	$621,583
														Subtotal = $621,583

Issue Date FY: 2019 ( Subtotal = $621,583 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	001	4	7/18/2019	NON-COMPETING CONTINUATION	$0
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	4	7/16/2019	NON-COMPETING CONTINUATION	$621,583
														Subtotal = $621,583

Issue Date FY: 2018 ( Subtotal = $650,531 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	3	5/10/2018	NON-COMPETING CONTINUATION	$650,531
														Subtotal = $650,531

Issue Date FY: 2017 ( Subtotal = $657,199 )
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	2	6/5/2017	NON-COMPETING CONTINUATION	$657,199
														Subtotal = $657,199

Issue Date FY: 2016 ( Subtotal = $707,284 )
2016	2016	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Child Health and Human Development Extramural Research	000	1	9/22/2016	NEW	$707,284
														Subtotal = $707,284

Grand Total All Awards = $3,867,330

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Development of a Modular Soft Exosuit Platform Suitable for Community-Based Neurorehabilitation

Award Number: R01HD088619

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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